I think this should be the default option for your donations (setting aside how much and when you want to donate), and you should either defer to them or make a serious effort to beat them (possibly with their help). You can talk to the fund managers for advice. These fund managers have a good idea if how money is being spent within their causes and how their grants/donations might affect where other funding goes (e.g. where Open Phil grants).
It could be worth asking them for estimates of the cost-effectiveness of their marginal grants, although I don’t know if they will actually keep track of this, and it could have extremely high uncertainty, depending on the cause.
Here is a great place to start: https://funds.effectivealtruism.org
I think this should be the default option for your donations (setting aside how much and when you want to donate), and you should either defer to them or make a serious effort to beat them (possibly with their help). You can talk to the fund managers for advice. These fund managers have a good idea if how money is being spent within their causes and how their grants/donations might affect where other funding goes (e.g. where Open Phil grants).
It could be worth asking them for estimates of the cost-effectiveness of their marginal grants, although I don’t know if they will actually keep track of this, and it could have extremely high uncertainty, depending on the cause.