In the abstract, the highest impact scientific research you can do outside industry should focus on things that are important to long-term success, but are not necessary in the short term.
Companies already have a strong incentive to find alternatives to the largest cost-drivers so that they can begin to produce regularly at smaller scales without going bankrupt. For example, companies are likely already working on alternatives to using the most expensive growth factors, since at current costs, they can make even small scale production cost-prohibitive.
However, the long term success of cultivated meat will require innovation and cost reduction across the entire value chain. Many of these innovations aren’t important for the short-term goals of the industry, so will likely get pushed off until later. This is where academic research can currently provide value.
One great candidate for this is developing ways to create dirt-cheap basal media from plants, e.g. using hydrolysates. Currently, basal media components are all sourced separately, and are often produced in inefficient ways. For example, individual amino acids are often produced via fermentation and then combined in a single media formulation. This is a much less efficient process compared to current meat production, where amino acids are sourced from soybeans and fed to animals. In the long term, it’s likely that cultivated meat will need to move to a system where the main basal media components are grown via agriculture as opposed to biotech. However, it’s likely difficult for companies to justify spending a lot of time on this, since basal media is not currently a major cost driver.