Hi, I agree ETOH is extremely harmful. However, there are existing medications which act on GABA, many of which are both highly addictive and therefore highly regulated themselves. Barbituates are a (now outdated) drug class which acts on GABA, others include benzodiazepines and more modern sleep drugs like Zolpidem. All have significant side effects.
This website strikes me as very selective in how scientific it is—for example, “At higher levels (blood ethanol >400mg%, as would occur after drinking a litre of vodka) then these two effects of ethanol – the increase in GABA inhibition and the blockade of glutamate excitation – can combine to produce a lethal level of sedation and respiratory depression. In terms of health impacts, alcohol (strictly speaking, ethanol) is in a class of its own, and very different from GABA.” ETOH is not that different from GABA, as you can also overdose and cause respiratory depression and death from GABA inhibition. I would like to see some more peer-reviewed studies around this new drink, and a comparison to placebo (if you’re giving people this drink and saying it will enhance “conviviality and relaxation” then it probably will).
As with pretty much anything health related, there’s no quick fix. Things which depress the CNS are addictive, and not that dissimilar from one another. I can see the marketing opportunity for this in the “health food” arena, which makes me more skeptical of this site. I imagine, if released, it may have a similar fate to cannabinoid molecules being included in all sorts of products—allowed because they are ineffective, or vapes—with a different risk profile to the original substance.
Hi, I agree ETOH is extremely harmful. However, there are existing medications which act on GABA, many of which are both highly addictive and therefore highly regulated themselves. Barbituates are a (now outdated) drug class which acts on GABA, others include benzodiazepines and more modern sleep drugs like Zolpidem. All have significant side effects.
This website strikes me as very selective in how scientific it is—for example, “At higher levels (blood ethanol >400mg%, as would occur after drinking a litre of vodka) then these two effects of ethanol – the increase in GABA inhibition and the blockade of glutamate excitation – can combine to produce a lethal level of sedation and respiratory depression. In terms of health impacts, alcohol (strictly speaking, ethanol) is in a class of its own, and very different from GABA.” ETOH is not that different from GABA, as you can also overdose and cause respiratory depression and death from GABA inhibition. I would like to see some more peer-reviewed studies around this new drink, and a comparison to placebo (if you’re giving people this drink and saying it will enhance “conviviality and relaxation” then it probably will).
As with pretty much anything health related, there’s no quick fix. Things which depress the CNS are addictive, and not that dissimilar from one another. I can see the marketing opportunity for this in the “health food” arena, which makes me more skeptical of this site. I imagine, if released, it may have a similar fate to cannabinoid molecules being included in all sorts of products—allowed because they are ineffective, or vapes—with a different risk profile to the original substance.