Executive summary: Despite significant progress, tuberculosis remains the deadliest infectious disease globally, killing 1.2 million people annually, but new vaccines, antibiotics, and drug discovery methods offer hope for meeting ambitious goals to reduce TB cases and deaths by 2030.
Key points:
The BCG vaccine developed in 1919 reduced TB deaths by 74%, but has variable efficacy and doesn’t protect all recipients.
Antibiotic resistance and long treatment regimens pose challenges for current TB therapies.
A new vaccine (M72/AS01E) shows promise in clinical trials, potentially offering better protection than BCG for adults.
Machine learning and AI are accelerating antibiotic discovery, identifying candidates like halicin and optimizing drug combinations.
Financial incentives remain a barrier to pharmaceutical industry engagement in TB research.
Historical successes in controlling other infectious diseases provide hope that TB can be significantly reduced with continued efforts and innovations.
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Executive summary: Despite significant progress, tuberculosis remains the deadliest infectious disease globally, killing 1.2 million people annually, but new vaccines, antibiotics, and drug discovery methods offer hope for meeting ambitious goals to reduce TB cases and deaths by 2030.
Key points:
The BCG vaccine developed in 1919 reduced TB deaths by 74%, but has variable efficacy and doesn’t protect all recipients.
Antibiotic resistance and long treatment regimens pose challenges for current TB therapies.
A new vaccine (M72/AS01E) shows promise in clinical trials, potentially offering better protection than BCG for adults.
Machine learning and AI are accelerating antibiotic discovery, identifying candidates like halicin and optimizing drug combinations.
Financial incentives remain a barrier to pharmaceutical industry engagement in TB research.
Historical successes in controlling other infectious diseases provide hope that TB can be significantly reduced with continued efforts and innovations.
This comment was auto-generated by the EA Forum Team. Feel free to point out issues with this summary by replying to the comment, and contact us if you have feedback.