Executive summary: Analysis of new wastewater sequencing data from the 2023-2024 flu season provides estimates of influenza detection sensitivity, showing lower relative abundance than previously estimated for SARS-CoV-2.
Key points:
New data from Missouri and California allows estimation of influenza A and B detection in wastewater during an active flu season.
Relative abundance of influenza in wastewater correlates with positive test rates, but with significant variability.
Estimated RAi(1%) for influenza A and B is lower than previous SARS-CoV-2 estimates, varying by sequencing protocol and location.
Findings will be used to update a metagenomic biosurveillance simulator, likely resulting in higher variance and less optimistic projections.
Further sequencing in the 2024-2025 season is expected to reduce uncertainty in these estimates.
This comment was auto-generated by the EA Forum Team. Feel free to point out issues with this summary by replying to the comment, andcontact us if you have feedback.
Executive summary: Analysis of new wastewater sequencing data from the 2023-2024 flu season provides estimates of influenza detection sensitivity, showing lower relative abundance than previously estimated for SARS-CoV-2.
Key points:
New data from Missouri and California allows estimation of influenza A and B detection in wastewater during an active flu season.
Relative abundance of influenza in wastewater correlates with positive test rates, but with significant variability.
Estimated RAi(1%) for influenza A and B is lower than previous SARS-CoV-2 estimates, varying by sequencing protocol and location.
Findings will be used to update a metagenomic biosurveillance simulator, likely resulting in higher variance and less optimistic projections.
Further sequencing in the 2024-2025 season is expected to reduce uncertainty in these estimates.
This comment was auto-generated by the EA Forum Team. Feel free to point out issues with this summary by replying to the comment, and contact us if you have feedback.