To highlight some that seem potentially relevant to your ask:
What are the effects of increasing the availability of animal-free foods on animal product consumption? Are alternatives to animal products actually used to replace animal products, and especially those that involve the most suffering? Which plant-based offerings are being used as substitutes versus complements for animal products and why?
Wellbeing measures/how to convert between DALY and WELLBY welfare measurements on assessing charities and interventions.
Is WELLBY the most appropriate (useful, reliable...) measure [for interventions that may have impacts on mental health]
What is cell-cultured meat likely to cost, by year, as a function of the level of investments made?
How often do countries honor their (international) agreements in the event of large catastrophes (and what determines this?)
How probable is it that cell-cultured meat will gain widespread consumer acceptance, and to what timescale? To what extent will consumers replace conventional meat with cell-cultured meat?
How important is democracy for resilience against global catastrophic risk?
How generalizable is evidence on the effectiveness of corporate animal welfare outreach [in the North] to the Global South?
How much will the US government use subjective forecasting approaches (in the way the DoD does) in the next ~50 years?
This seems a bit related to the “Pivotal questions”: an Unjournal trial initiative -- we’ve engaged with a small group of organizations and elicited some of these—see here.
To highlight some that seem potentially relevant to your ask: