One great example is the pain gap / access abyss. Only coined around 2017, got some attention at EA Global London 2017 (?), then OPIS stepped up. I don’t think the OPIS staff were doing a cause-neutral search for this (they were founded 2016) so much as it was independent convergence.
Their website suggests it wasn’t independent.
‘The primary issue for OPIS is the ethical imperative to reduce suffering. Linked to the effective altruism movement, they choose causes that are most likely to produce the largest impact, determined by what Leighton calls “a clear underlying philosophy which is suffering-focused”.’
I may be wrong, but I remember reading an EA profile report and seeing Leighton comment that the profile report inspired OPIS’s movement toward working on the problem.