By not tolerated we mean that Excruciating pain can’t be sustained for long (e.g., hours, as opposed to minutes) without neurological shutdown. It will tend to overrides an organism’s ability to function or respond coherently, with even powerful opioids providing minimal relief, or desperate attempts to escape pain even at the risk of death . Examples would include severe burning in large areas of the body, dismemberment, or extreme torture. Examiing empirically trade-offs with milder pain could be interesting, but may be challenging given the nature of truly excruciating pain . Perhaps comparing to severe but more sustained pain (like bone fractures)?
By not tolerated we mean that Excruciating pain can’t be sustained for long (e.g., hours, as opposed to minutes) without neurological shutdown. It will tend to overrides an organism’s ability to function or respond coherently, with even powerful opioids providing minimal relief, or desperate attempts to escape pain even at the risk of death . Examples would include severe burning in large areas of the body, dismemberment, or extreme torture.
Examiing empirically trade-offs with milder pain could be interesting, but may be challenging given the nature of truly excruciating pain . Perhaps comparing to severe but more sustained pain (like bone fractures)?