Reviews are good for short-term common side effects, not as good for rare or delayed severe ones. Would an analysis of Reddit and Amazon reviews of thalidomide have revealed its negative effects? Bex powder? Diethylstilbestrol? Betel nut?
Thanks, Henry. Your care, as a doctor, for people’s wellbeing shines through! We’d also hate to learn that this herb causes e.g. delayed, severe side effects. We hope this question can be settled for good asap given the scope and severity of the suffering involved here!
We start our post acknowledging that online reviews are not usually a reliable source of information concerning medical matters. So we asked ourselves: if there was a statistically significant signal, how could we possibly find it? This is what motivated us to:
Compare reviews across three different platforms (WebMD, Amazon, Reddit).
Compare reviews of chanca piedra to reviews of other kidney stone treatments within those same platforms.
Compare reviews of other popular supplements within those same platforms (e.g., ashwagandha, melatonin).
Do sub-analyses of the data, e.g. looking only at the most credible reviews and reading closely any reviews mentioning any severe or rare side effects (which we report).
Look into whatever literature we could find about chanca piedra to see if mechanistic explanations were compatible with our findings.
Would an analysis of Reddit and Amazon reviews of thalidomide have revealed its negative effects? Bex powder? Diethylstilbestrol? Betel nut?
Not necessarily, no. But if we had access to thousands of anecdotes and reviews of these medications dating back to 2008, including by people who have taken them for years, the chances would go up significantly. I guess that’s our main “selling point”.
In the end, our goal is to reduce as much extreme suffering as possible. If it turns out that taking chanca piedra actually increases extreme suffering, we’d want to be the first ones to know! But from what we can tell, that hypothesis is looking very unlikely.
Am reminded of this XKCD:
Reviews are good for short-term common side effects, not as good for rare or delayed severe ones.
Would an analysis of Reddit and Amazon reviews of thalidomide have revealed its negative effects? Bex powder? Diethylstilbestrol? Betel nut?
Thanks, Henry. Your care, as a doctor, for people’s wellbeing shines through! We’d also hate to learn that this herb causes e.g. delayed, severe side effects. We hope this question can be settled for good asap given the scope and severity of the suffering involved here!
We start our post acknowledging that online reviews are not usually a reliable source of information concerning medical matters. So we asked ourselves: if there was a statistically significant signal, how could we possibly find it? This is what motivated us to:
Compare reviews across three different platforms (WebMD, Amazon, Reddit).
Compare reviews of chanca piedra to reviews of other kidney stone treatments within those same platforms.
Compare reviews of other popular supplements within those same platforms (e.g., ashwagandha, melatonin).
Do sub-analyses of the data, e.g. looking only at the most credible reviews and reading closely any reviews mentioning any severe or rare side effects (which we report).
Look into whatever literature we could find about chanca piedra to see if mechanistic explanations were compatible with our findings.
Not necessarily, no. But if we had access to thousands of anecdotes and reviews of these medications dating back to 2008, including by people who have taken them for years, the chances would go up significantly. I guess that’s our main “selling point”.
In the end, our goal is to reduce as much extreme suffering as possible. If it turns out that taking chanca piedra actually increases extreme suffering, we’d want to be the first ones to know! But from what we can tell, that hypothesis is looking very unlikely.