FYI the E-QALY work has been progressing quite well since you asked that question; I’ve just come out of a webinar on it. Let me know if you want me to send you notes/slides.
A few key points:
The measure has been named the EuroQol Health and Wellbeing (EQ-HWB); E-QALY seems to be what they are calling the broader project of extending the scope of the QALY.
Psychometric work and stakeholder consultation resulting in a 25-item ‘long’ measure, then further consultation resulted in a 9-item EQ-HWB-S (Short Form) covering 9 domains: Mobility, Daily activitie, Pain, Fatigue, Loneliness, Concentration & thinking clearly, Depression, Anxiety, Control.
A feasibility valuation study in 521 members of the UK public uses the time tradeoff (TTO, EQ-VT protocol) and discrete choice experiments (DCE). Due to covid this was done using video conferencing.
There was also a deliberative exercise with a 12-member panel of experts at NICE which reviewed the valuation results.
Based on the size of the utility decrement associated with the most severe level of each dimension, the order of importance is: Pain (by a long way); Mobility; Daily activities; Depression; Loneliness; Anxiety; Fatigue; Control; Concentration. (To me, the weight given to Mobility in particular might indicate that this measure does not overcome some of the biggest problems with earlier measures like the EQ-5D, though it seems to be much better overall.)
Other valuation studies, using different methodologies, are underway or planned. As far as I know, these don’t include ones that obtain weights based on SWB, but I think they will be looking at own-state utilities (i.e. weights derived from preferences of people with the relevant conditions).
Several papers are being published on it this year in a special edition of the journal Value in Health.
It started with a grant of 850,000 GBP; more has been spent since, but I’m not sure how much.
NICE still seems wedded to the EQ-5D for the foreseeable future, at least in standard health technology assessments, but they may use/accept the EQ-HWB in cases where broader effects are particularly important, e.g. impacts on carers.
Mukuria, C et al. “Qualitative Review on Domains of Quality of Life Important for Patients, Social Care Users, and Informal Carers to Inform the Development of the EQ Health and Wellbeing.” Value in Health (2022).
Monteiro AL, et al. A Comparison of a Preliminary Version of the EQ Health and Wellbeing Short and the 5-Level Version EQ-5D. Value Health. 2022 Mar 8:S1098-3015(22)00051-1. doi: 10.1016/j.jval.2022.01.003. Epub ahead of print. PMID: 35279371.
FYI the E-QALY work has been progressing quite well since you asked that question; I’ve just come out of a webinar on it. Let me know if you want me to send you notes/slides.
A few key points:
The measure has been named the EuroQol Health and Wellbeing (EQ-HWB); E-QALY seems to be what they are calling the broader project of extending the scope of the QALY.
Psychometric work and stakeholder consultation resulting in a 25-item ‘long’ measure, then further consultation resulted in a 9-item EQ-HWB-S (Short Form) covering 9 domains: Mobility, Daily activitie, Pain, Fatigue, Loneliness, Concentration & thinking clearly, Depression, Anxiety, Control.
A feasibility valuation study in 521 members of the UK public uses the time tradeoff (TTO, EQ-VT protocol) and discrete choice experiments (DCE). Due to covid this was done using video conferencing.
There was also a deliberative exercise with a 12-member panel of experts at NICE which reviewed the valuation results.
Based on the size of the utility decrement associated with the most severe level of each dimension, the order of importance is: Pain (by a long way); Mobility; Daily activities; Depression; Loneliness; Anxiety; Fatigue; Control; Concentration. (To me, the weight given to Mobility in particular might indicate that this measure does not overcome some of the biggest problems with earlier measures like the EQ-5D, though it seems to be much better overall.)
Other valuation studies, using different methodologies, are underway or planned. As far as I know, these don’t include ones that obtain weights based on SWB, but I think they will be looking at own-state utilities (i.e. weights derived from preferences of people with the relevant conditions).
Several papers are being published on it this year in a special edition of the journal Value in Health.
It started with a grant of 850,000 GBP; more has been spent since, but I’m not sure how much.
NICE still seems wedded to the EQ-5D for the foreseeable future, at least in standard health technology assessments, but they may use/accept the EQ-HWB in cases where broader effects are particularly important, e.g. impacts on carers.
[Recording of the talk and related papers]
You can now view the recording of the talk from Professor John Brazier—Extending the QALY beyond health—the EQ HWB (Health and Wellbeing)
Kaltura
https://digitalmedia.sheffield.ac.uk/media/t/1_8k5slrc4
YouTube
https://www.youtube.com/watch?v=KTlsIvqyhNI
Papers associated with this talk
Special issue of Value in Health Development papers:
Brazier, J et al. ‘The EQ-HWB: overview of the development of a measure of health and well-being and key results’. Value in Health. https://www.sciencedirect.com/science/article/pii/S1098301522000833
Mukuria, C et al. “Qualitative Review on Domains of Quality of Life Important for Patients, Social Care Users, and Informal Carers to Inform the Development of the EQ Health and Wellbeing.” Value in Health (2022).
https://www.sciencedirect.com/science/article/pii/S1098301521032277
Carlton, J et al. “Generation, Selection, and Face Validation of Items for a New Generic Measure of Quality of Life: The EQ Health and Wellbeing.” Value in Health (2022). https://www.sciencedirect.com/science/article/pii/S1098301522000109
Peasgood, T et al. “Developing a New Generic Health and Wellbeing Measure: Psychometric Survey Results for the EQ Health and Wellbeing.” Value in Health (2022). https://www.sciencedirect.com/science/article/pii/S1098301521031922
International papers:
Monteiro AL, et al. A Comparison of a Preliminary Version of the EQ Health and Wellbeing Short and the 5-Level Version EQ-5D. Value Health. 2022 Mar 8:S1098-3015(22)00051-1. doi: 10.1016/j.jval.2022.01.003. Epub ahead of print. PMID: 35279371.
Augustovski F, Argento F, Rocío R, Luz G, Mukuria C, Belizán M. The Development of a New International Generic Measure (EQ Health and Wellbeing): Face Validity And Psychometric Stages In Argentina. https://www.sciencedirect.com/science/article/abs/pii/S1098301522000134