Yes there is some research on this. We found in survey research the personality trait of neuroticism is associated with more difficult psychedelic experiences: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540159/
The Vollenweider lab has found that the personality trait of absorption in lab research was associated with greater pleasant and mystical experiences, and emotional excitability was associated with unpleasant and anxious reactions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281871/
Yes there is some research on this. We found in survey research the personality trait of neuroticism is associated with more difficult psychedelic experiences: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540159/
The Vollenweider lab has found that the personality trait of absorption in lab research was associated with greater pleasant and mystical experiences, and emotional excitability was associated with unpleasant and anxious reactions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281871/