Yes, I’d bet the effects are even smaller than what this study found. This study gives a small amount of evidence of an effect > 0.05 SD. But without a clear mechanism I think an effect of < 0.05 SD is significantly more likely. One of the main reasons we were expecting an effect here was a prior literature that is now looking pretty bad.
That said, this was definitely some evidence for a positive effect, and the prior literature is still some evidence for a positive effect even if it’s not looking good. And the upside is pretty large here since creatine supplementation is cheap. So I think this is good enough grounds for me to be willing to fund a larger study.
Yes, I’d bet the effects are even smaller than what this study found. This study gives a small amount of evidence of an effect > 0.05 SD. But without a clear mechanism I think an effect of < 0.05 SD is significantly more likely. One of the main reasons we were expecting an effect here was a prior literature that is now looking pretty bad.
That said, this was definitely some evidence for a positive effect, and the prior literature is still some evidence for a positive effect even if it’s not looking good. And the upside is pretty large here since creatine supplementation is cheap. So I think this is good enough grounds for me to be willing to fund a larger study.