I personally don’t find the ITN framework useful and agree with most of John Halstead’s criticism of the framework here. Cost-effectiveness seems better if you want to make something numerical, within a particular cause area.
In fact, for me, I think both cost-effectiveness and ITN as intellectual frameworks fall down because they mask what I see as a fundamentally philosophical set of questions, if you’re trying to do something like compare mental health with health interventions with animal welfare with more longtermist interventions.
If there’s an underlying question: how does one prioritise causes? From my own perspective, I just gravitated towards a more longtermist cause prioritisation over time as I found the arguments quite convincing, but I agree that many other areas are extremely worthwhile.