I previously argued against EAs volunteering for challenge trials with pathogens without a known cure (like Zika) and with risk of long-term illness: https://forum.effectivealtruism.org/posts/kKidKRiCcZ5uGJ6w5/stop-thinking-about-ftx-think-about-getting-zika-instead?commentId=FTmfA8AWnQ7yta77P
I think HCV is a very different situation, and has a very acceptable risk profile given the available therapeutics.
I previously argued against EAs volunteering for challenge trials with pathogens without a known cure (like Zika) and with risk of long-term illness: https://forum.effectivealtruism.org/posts/kKidKRiCcZ5uGJ6w5/stop-thinking-about-ftx-think-about-getting-zika-instead?commentId=FTmfA8AWnQ7yta77P
I think HCV is a very different situation, and has a very acceptable risk profile given the available therapeutics.