Effective Help[1] is a small EA-inspired Cameroonian[2] organization trying to identify local cost-effective projects. We analysed data from 39 local projects and found one standing out, a small monthly cash transfer to families with a child or more suffering from sickle cell anaemia. We decided to partner with the NGO carrying out this project and raise funds for it.
We think this is a good way forward for us. Please go through our thinking below and tell us how to improve.
Questions:
How bad is sickle cell anaemia in Sub-Saharan Africa (Cameroon in particular) for those who suffer it?
Are cash transfers to families with children suffering from this problem a cost-effective form of reducing mortality and improving quality of life?
Our position: We don’t think this is as cost-effective as some of the best causes globally, but we think it compares much better to other local NGOs in Cameroon and to other projects in crowdfunding sites, so we are comfortable raising more funds away from less cost-effective causes and towards this one. The worst that can happen is that we transfer funds to a poor family, at a slightly higher cost than GiveDirectly (because of the small scale of the project, overhead is proportionally higher) and the best is that we save children from early deaths and make them win years of life with as little as 49USD a month (588 a year).
We also think the first family identified has such a brutal story, which we won’t share here, that the children are significantly worse-off than the average children with sickle cell in Cameroon. We think the effect of the first donations securing the next 3 years of transfers for this family should be higher than if the project had a larger scale and covered hundreds of families systematically. On the other hand, there is a point to be made about prioritizing families when the child is between 1 and 3 years of age and mortality peaks, and this specific family has already passed that stage.
We have much better data from developed countries. Life expectancy with sickle cell anaemia could be 42 years for males and 48 for women, as opposed to 75 and 82.[3] Sickle cell-hemoglobin C disease is a bit better: 60 for males and 68 for females.
One of the studies we use as a reference followed 3,764 patients of different ages[4], and included investigation on 209 patients who died. 33% of those who died, died during an acute sickle crisis, and there was a high correlation between early death and some key symptoms of sickle cell anaemia: acute chest syndrome, renal failure, and seizures.
The information available tells us those living with sickle cell are very likely already to have a shorter life, even when they are accessing good treatment. This is sad and may reduce potential cost-effectiveness for our project (even in the best circumstances, patients tend to live less).
How much of the danger can be mitigated with treatment? How much worse is it without treatment?
Without treatment or with bad treatment most children die without reaching adulthood. As late as 1973, the median survival age was reported to be 14 years, and 20% of children died within two years.
So, we think regular treatment can more than triple life expectancy, over time adding 28 years to someone.
Also, mortality is worse the younger the person gets, it peaks between years 1 and 3.
How bad is sickle cell anaemia in developing countries?
Research on sickle cell in developing countries is less detailed and it is not easy to draw a number. Mortality rate could be 50% to 80% for children below five years.[5] The data from 1973 may be a good reference because in sub-Saharan Africa as many as 50 to 90% of children with this condition are estimated to reach the 5th year or die without a diagnosis.[6]
Studies report an interaction between malaria and sickle cell, possible preventing some of the damage caused by malaria, making patients slightly more resistant than the average child with malaria. [7] This potentially could reduce the effect of the intervention, but there is an abundance of bacterial infections that interact very negatively with sickle cell anaemia. This potentially beneficial effect of sickle cell could hint why is it so spread in Sub-Saharan Africa.
The project
Once a family is identified, they receive about 49 USD a month, roughly estimated to be half for food and half for medical costs. These are mobile money transfers and there is no counseling or coaching work, or income-generating element. We think this is good because it would increase the cost per family, even if there are potential beneficial effects in such activities. There is also no prevention or awareness-raising element. Cameroon health system tries to avoid this infection by getting couples tested before marriage, which is a sensible process but misses large parts of the population. The project also does not try to identify children whose parents may not be aware of their condition, which could be a potentially more cost-effective intervention, but if it is implemented at scale may have a calling effect at some point, families may be more interested in getting their children tested.
There are families identified, should more funds be raised, and potentially hundreds could be identified through local health centers.
[1] Yes, we realize this name is not very creative.
[2] In our first year, we were a grantee of the EA Infrastructure Fund, we thank them for their donation that helped us set up our structure and identify this project.
Critique our position – Sickle cell anaemia in sub-Saharan Africa (Cameroon)
There is a good post exploring sickle cell disease, here: [Cause Exploration Prizes] Sickle Cell Disease — EA Forum (effectivealtruism.org). This is a good starting point before reading this one.
Effective Help[1] is a small EA-inspired Cameroonian[2] organization trying to identify local cost-effective projects. We analysed data from 39 local projects and found one standing out, a small monthly cash transfer to families with a child or more suffering from sickle cell anaemia. We decided to partner with the NGO carrying out this project and raise funds for it.
We think this is a good way forward for us. Please go through our thinking below and tell us how to improve.
Questions:
How bad is sickle cell anaemia in Sub-Saharan Africa (Cameroon in particular) for those who suffer it?
Are cash transfers to families with children suffering from this problem a cost-effective form of reducing mortality and improving quality of life?
Our position: We don’t think this is as cost-effective as some of the best causes globally, but we think it compares much better to other local NGOs in Cameroon and to other projects in crowdfunding sites, so we are comfortable raising more funds away from less cost-effective causes and towards this one. The worst that can happen is that we transfer funds to a poor family, at a slightly higher cost than GiveDirectly (because of the small scale of the project, overhead is proportionally higher) and the best is that we save children from early deaths and make them win years of life with as little as 49USD a month (588 a year).
We also think the first family identified has such a brutal story, which we won’t share here, that the children are significantly worse-off than the average children with sickle cell in Cameroon. We think the effect of the first donations securing the next 3 years of transfers for this family should be higher than if the project had a larger scale and covered hundreds of families systematically. On the other hand, there is a point to be made about prioritizing families when the child is between 1 and 3 years of age and mortality peaks, and this specific family has already passed that stage.
You can check out the project on this page. Help children with sickle cell syndrome—GlobalGiving and other sickle-cell projects in GlobalGiving here: Search—GlobalGiving
How bad is sickle cell anaemia?
We have much better data from developed countries. Life expectancy with sickle cell anaemia could be 42 years for males and 48 for women, as opposed to 75 and 82.[3] Sickle cell-hemoglobin C disease is a bit better: 60 for males and 68 for females.
One of the studies we use as a reference followed 3,764 patients of different ages[4], and included investigation on 209 patients who died. 33% of those who died, died during an acute sickle crisis, and there was a high correlation between early death and some key symptoms of sickle cell anaemia: acute chest syndrome, renal failure, and seizures.
The information available tells us those living with sickle cell are very likely already to have a shorter life, even when they are accessing good treatment. This is sad and may reduce potential cost-effectiveness for our project (even in the best circumstances, patients tend to live less).
How much of the danger can be mitigated with treatment? How much worse is it without treatment?
Without treatment or with bad treatment most children die without reaching adulthood. As late as 1973, the median survival age was reported to be 14 years, and 20% of children died within two years.
So, we think regular treatment can more than triple life expectancy, over time adding 28 years to someone.
Also, mortality is worse the younger the person gets, it peaks between years 1 and 3.
How bad is sickle cell anaemia in developing countries?
Research on sickle cell in developing countries is less detailed and it is not easy to draw a number. Mortality rate could be 50% to 80% for children below five years.[5] The data from 1973 may be a good reference because in sub-Saharan Africa as many as 50 to 90% of children with this condition are estimated to reach the 5th year or die without a diagnosis.[6]
Studies report an interaction between malaria and sickle cell, possible preventing some of the damage caused by malaria, making patients slightly more resistant than the average child with malaria. [7] This potentially could reduce the effect of the intervention, but there is an abundance of bacterial infections that interact very negatively with sickle cell anaemia. This potentially beneficial effect of sickle cell could hint why is it so spread in Sub-Saharan Africa.
The project
Once a family is identified, they receive about 49 USD a month, roughly estimated to be half for food and half for medical costs. These are mobile money transfers and there is no counseling or coaching work, or income-generating element. We think this is good because it would increase the cost per family, even if there are potential beneficial effects in such activities. There is also no prevention or awareness-raising element. Cameroon health system tries to avoid this infection by getting couples tested before marriage, which is a sensible process but misses large parts of the population. The project also does not try to identify children whose parents may not be aware of their condition, which could be a potentially more cost-effective intervention, but if it is implemented at scale may have a calling effect at some point, families may be more interested in getting their children tested.
There are families identified, should more funds be raised, and potentially hundreds could be identified through local health centers.
[1] Yes, we realize this name is not very creative.
[2] In our first year, we were a grantee of the EA Infrastructure Fund, we thank them for their donation that helped us set up our structure and identify this project.
[3] Life expectancy worldwide by development level 2023 | Statista
[4] Mortality In Sickle Cell Disease—Life Expectancy and Risk Factors for Early Death | New England Journal of Medicine (nejm.org)
[5] A Critical Review of Sickle Cell Disease Burden and Challenges in Sub-Saharan Africa—PMC (nih.gov)
[6] Sickle Cell Disease in Sub-Saharan Africa—PMC (nih.gov)
[7] Sickle Cell Disease in Sub-Saharan Africa—PMC (nih.gov)