Definitely there’s no single gene that controls mood, I think it’s agreed that it’s a combination of many factors, genetic and otherwise. But, strong correlations do exist between some alleles and subjective wellbeing. 5-HTT and FAAH are two genes with such alleles, off the top of my head.
Did GWAS collect data on subjective wellbeing? I have seen that they have some data on severe mental disorders, but that’s not the same thing. I have wondered before about trying to collect a genomic database along with self-reported mood data, I think that would be massively useful, if it’s been done I haven’t seen it.
Depression =/= low mood. Its just one of a plethora of ways to have sustained periods of low mood. The real question is how larger proportion of mood is determined by the top genes
isn’t this a little bit optimistic given the massively polygenic nature of depression?
Definitely there’s no single gene that controls mood, I think it’s agreed that it’s a combination of many factors, genetic and otherwise. But, strong correlations do exist between some alleles and subjective wellbeing. 5-HTT and FAAH are two genes with such alleles, off the top of my head.
pretty sure that’s all stuff from the candidate gene era that didn’t replicate in GWAS. Population structure is a real bitch unfortunately
Did GWAS collect data on subjective wellbeing? I have seen that they have some data on severe mental disorders, but that’s not the same thing. I have wondered before about trying to collect a genomic database along with self-reported mood data, I think that would be massively useful, if it’s been done I haven’t seen it.
Depression =/= low mood. Its just one of a plethora of ways to have sustained periods of low mood. The real question is how larger proportion of mood is determined by the top genes