Yes, I saw that case. It seems that they were using an extremely high viral dosage. In my understanding one of the reasons AAV is typically used is the low immunogenicity at normal dosages and overall good safety profile. Obviously no pioneering method is without risk.
Whether mood disorders qualify under your criteria is debatable—certainly for a large proportion of people no currently available treatment is effective. Fatality rates may be relatively low, but I suspect a fairly large cohort of people living with mood disorders would rather tolerate some risk than live out the rest of their lives with no hope of treatment.
Yes, I saw that case. It seems that they were using an extremely high viral dosage. In my understanding one of the reasons AAV is typically used is the low immunogenicity at normal dosages and overall good safety profile. Obviously no pioneering method is without risk.
Whether mood disorders qualify under your criteria is debatable—certainly for a large proportion of people no currently available treatment is effective. Fatality rates may be relatively low, but I suspect a fairly large cohort of people living with mood disorders would rather tolerate some risk than live out the rest of their lives with no hope of treatment.