Not really answering your question, but there is some recent work attempting to forecast clinical trial results that may be relevant: Can Oncologists Predict the Efficacy of Treatments in Randomized Trials? Kimmelman (the senior author) is doing other work on the topic too (e.g. here). Iām not aware of much published work in this space in a biomedical context.
My guess is that key decision makers in medicine (e.g. funders of trials), would not be very open to paying attention to forecasts (even if shown to be accurate to some degree), as there is a very strong culture of relying on data and in particular on RCTs.
Not really answering your question, but there is some recent work attempting to forecast clinical trial results that may be relevant: Can Oncologists Predict the Efficacy of Treatments in Randomized Trials? Kimmelman (the senior author) is doing other work on the topic too (e.g. here). Iām not aware of much published work in this space in a biomedical context.
My guess is that key decision makers in medicine (e.g. funders of trials), would not be very open to paying attention to forecasts (even if shown to be accurate to some degree), as there is a very strong culture of relying on data and in particular on RCTs.