The final table in the Supplement is essential to understanding the conclusion of the above study published recently in Nature Medicine—in summary sodium reduction per se didn’t have an impact, but as best I can tell that could be because sodium reduction wasn’t achieved at all.
Very nice summary, Joel. Please note that in addition to the SSASS cluster-randomized clinical trial https://www.nejm.org/doi/full/10.1056/nejmoa2105675, there has also been this more recent cluster-randomized potassium substitution trial: https://www.nature.com/articles/s41591-023-02286-8 & an older cluster-randomized potassium substitution trial https://www.sciencedirect.com/science/article/pii/S0002916523294599?via%3Dihub.
The final table in the Supplement is essential to understanding the conclusion of the above study published recently in Nature Medicine—in summary sodium reduction per se didn’t have an impact, but as best I can tell that could be because sodium reduction wasn’t achieved at all.
This article by Derek Denton offers a great deal of useful information on this topic: https://www.nature.com/articles/1000489.