Hey, I think you are right. I myself am doing my Masters in Nutrition and Biomedicine and have been reading up a lot on preventive cardiology (lipids, statins, etc.) over the last few months. Here are some more papers that I think are good and may be helpful for argumentation:
https://pubmed.ncbi.nlm.nih.gov/28444290/ (Probably the most influential paper on the topic of LDL and atherosclerosis—a consensus statement from the European Atherosclerosis Society).
In addition, leaders in the field like Thomas Dayspring or Allan Sniderman (you cited some papers of his anyway) are good places to go for information (e.g., the podcasts with Peter Attia, which you may already know anyway).
Personally, I’m still under 30 and have “optimal” non-HDL-C levels according to guidelines, but I’ll probably take a low-dose statin to get to under 100 mg/dl or LDL-C under 70 mg/dl or ApoB to about 60 mg/dl. At least for me, that is not achievable with lifestyle alone.
In addition, Lp(a) is still an important point. This is genetically determined and cannot (yet) really be influenced, but with a high value the treatment should be all the more aggressive.
Hey, I think you are right. I myself am doing my Masters in Nutrition and Biomedicine and have been reading up a lot on preventive cardiology (lipids, statins, etc.) over the last few months. Here are some more papers that I think are good and may be helpful for argumentation:
https://pubmed.ncbi.nlm.nih.gov/28444290/ (Probably the most influential paper on the topic of LDL and atherosclerosis—a consensus statement from the European Atherosclerosis Society).
https://www.sciencedirect.com/science/article/pii/S2666667722000551 (Very good overview including line of argument for earlier and more aggressive treatment)
https://pubmed.ncbi.nlm.nih.gov/15172426/ (Optimal LDL levels)
https://pubmed.ncbi.nlm.nih.gov/29241485/ (Linear relationship between LDL-C and atherosclerosis even in the “normal” range)
In addition, leaders in the field like Thomas Dayspring or Allan Sniderman (you cited some papers of his anyway) are good places to go for information (e.g., the podcasts with Peter Attia, which you may already know anyway).
Personally, I’m still under 30 and have “optimal” non-HDL-C levels according to guidelines, but I’ll probably take a low-dose statin to get to under 100 mg/dl or LDL-C under 70 mg/dl or ApoB to about 60 mg/dl. At least for me, that is not achievable with lifestyle alone.
In addition, Lp(a) is still an important point. This is genetically determined and cannot (yet) really be influenced, but with a high value the treatment should be all the more aggressive.