Hi Hauke, Thank you very much for this suggestion. Yes, animal models would be another category 2 option. You might know that Barry Marshall had much trouble developing animals models of Helicobacter pylori-induced gastritis, so this approach is hit-and-miss at best, and it is hard to know ahead of time what the probability of a “hit” would be. It is also less ethical than the other solutions, and for this reason, I’d prefer avoiding animal models (if possible).
This might be naive and I have only skimmed this thread, but wouldn’t using a cheap study using mouse model be best here? Maybe contact the authors of the papers cited in this paper “Mouse models of inflammatory bowel disease for investigating mucosal immunity in the intestine” to collaborate on such a study.
Hi Hauke, Thank you very much for this suggestion. Yes, animal models would be another category 2 option. You might know that Barry Marshall had much trouble developing animals models of Helicobacter pylori-induced gastritis, so this approach is hit-and-miss at best, and it is hard to know ahead of time what the probability of a “hit” would be. It is also less ethical than the other solutions, and for this reason, I’d prefer avoiding animal models (if possible).