The fact that no new hallmark has been discovered in decades is probably telling. But I think it is reasonable to believe that there are different hallmarks that will be visible in longer-than-human lifespans.
A lot of hallmarks (eg genetic mosaicism or improper stoichiometry or proteins not doing what they’re “supposed to do”) are systems effects rather than effects that can be analyzed reductionistically. Fedichev and Gladyshev have lots of papers that hint in that direction
To step back even earlier in the research pipeline, do you have any idea if there could be additional hallmarks to be found?
I look forward to the next post!
The fact that no new hallmark has been discovered in decades is probably telling. But I think it is reasonable to believe that there are different hallmarks that will be visible in longer-than-human lifespans.
A lot of hallmarks (eg genetic mosaicism or improper stoichiometry or proteins not doing what they’re “supposed to do”) are systems effects rather than effects that can be analyzed reductionistically. Fedichev and Gladyshev have lots of papers that hint in that direction