One point to consider is that if there really are large gains from scale, small donors can make risky bets to buy a chance of getting large, e.g. if large donors can get triple cost-effectiveness, then it would make sense to go to Las Vegas, and then if you win buy out-of-the-money options, to convert a small amount of money into a chance at a large amount. I have blog post discussing this.
In the same vein, you can give to big donors, or coordinate with them to let them allocate your donations.
One point to consider is that if there really are large gains from scale, small donors can make risky bets to buy a chance of getting large, e.g. if large donors can get triple cost-effectiveness, then it would make sense to go to Las Vegas, and then if you win buy out-of-the-money options, to convert a small amount of money into a chance at a large amount. I have blog post discussing this.
In the same vein, you can give to big donors, or coordinate with them to let them allocate your donations.