My best guess—this is a noisy estimate from a meta-analysis which doesn’t clearly report risk-of-bias assessments of included studies, so the mortality reduction is probably a lot smaller than 30%.
The time in the past where water filtration caused a mortality reduction greater than expected from eliminating typhoid—I imagine we can attribute large amounts to other infectious diseases like cholera, rotavirus etc?
Yes it’s noisy, but the funnel plot looks ok and in this case I don’t think major publication bias is likely. I would be very surprised if more than say 1 major study on this topic was not published.
Yeah the typhoid thing is super interesting. I didn’t look into it closely, but I suspect when they say “typhoid” they will be including many other diarrhoeal diseases under that banner too. Our microbial knowledge was pretty poor in the early 1900s.
My best guess—this is a noisy estimate from a meta-analysis which doesn’t clearly report risk-of-bias assessments of included studies, so the mortality reduction is probably a lot smaller than 30%.
The time in the past where water filtration caused a mortality reduction greater than expected from eliminating typhoid—I imagine we can attribute large amounts to other infectious diseases like cholera, rotavirus etc?
Yes it’s noisy, but the funnel plot looks ok and in this case I don’t think major publication bias is likely. I would be very surprised if more than say 1 major study on this topic was not published.
Yeah the typhoid thing is super interesting. I didn’t look into it closely, but I suspect when they say “typhoid” they will be including many other diarrhoeal diseases under that banner too. Our microbial knowledge was pretty poor in the early 1900s.