The large number of mutations with age recent studies are finding in some human tissues showcase how difficult it will be to significantly intervene in aging because we can’t easily get rid of mutant cells and replace them by pristine cells.
https://www.nature.com/articles/d41586-018-07737-8 is very deep too—actually it hints that many older cells are dominated by pro-growth/pro-survival mutations that don’t complete all the necessary conditions for cancer (but it just shows how cancer is the adaptive response of A LOT of other responses that are pro-growth/survival in ordinary cells that USUALLY don’t result in cancer...)
more on mosaicism—https://twitter.com/jpsenescence/status/1084560766735450113
https://www.nature.com/articles/d41586-018-07737-8 is very deep too—actually it hints that many older cells are dominated by pro-growth/pro-survival mutations that don’t complete all the necessary conditions for cancer (but it just shows how cancer is the adaptive response of A LOT of other responses that are pro-growth/survival in ordinary cells that USUALLY don’t result in cancer...)
There’s no compelling evidence that these kinds of mutations cause bad stuff to happen in a normal lifespan.