I wrote a quick draft on reasons you might want to skip pre-deployment Phase 3 drug trials (and instead do an experimental rollout with post-deployment trials, with option of recall) for vaccines for high diseases with high mortality burden, or for novel pandemics. https://inchpin.substack.com/p/skip-phase-3
It’s written in a pretty rushed way, but I know this idea has been bouncing around for a while and I haven’t seen a clearer writeup elsewhere, so I hope it can start a conversation!
I wrote a quick draft on reasons you might want to skip pre-deployment Phase 3 drug trials (and instead do an experimental rollout with post-deployment trials, with option of recall) for vaccines for high diseases with high mortality burden, or for novel pandemics. https://inchpin.substack.com/p/skip-phase-3
It’s written in a pretty rushed way, but I know this idea has been bouncing around for a while and I haven’t seen a clearer writeup elsewhere, so I hope it can start a conversation!