I am wondering if there is work being done on changing the brains of farm animals to increase their welfare levels without changing their environments. From what I know about the state of gene editing, it is possible to create smarter mice and flies that like cocaine, so it doesn’t seem like that much of a stretch to make a happier chicken or silkworm. If you have any relevant information, please share!
[Question] CRISPR for Happier Farm Animals?
Douglass Adams’s cow: http://thealmightyguru.com/Wiki/index.php?title=The_cow_that_wants_to_be_eaten
Hi! Have little time but have spoken with someone who was really excited about the potential of:
https://www.ucl.ac.uk/news/2023/may/study-reveals-unique-molecular-machinery-woman-who-cant-feel-pain
https://www.faroutinitiative.com/
this seems to be an org pursuing this
Wow, very helpful! They do seem to be doing just that. I will investigate them.
This is a really great idea, in my opinion. One alternative approach is breeding for lack of pain and happiness. We have made chickens much larger and lay eggs much more frequently. It is also possible to have animals that do not feel stress, anxiety, or suffer with enough breeding. If we identified gene variants associated with these, we could speed up the process with gene editing or some other tech.
Beyond animal suffering, the land/water/feed/antibiotic overusage, methane emissions, slaughterhouse worker conditions, zoonotic pandemics, etc still seem problematic
I couldn’t agree more. And yet… if the billions of farm animals could be engineered to have ridiculously high welfare levels, could that not overcome those very real concerns you point out? Has someone researched the welfare effects of the ancillary activities attached to farm animals?
Epistemic Status: hare-brained scheme
I think it might be possible to selectively interfere with any region of an animals brain using a sophisticated genetic logic gate. It’d even pass on in the germline so you’d only have to do the manipulation once or twice to get a new phenotype you can grow exponential via regular old breeding. They work a bit like this. If A and B and C but not D, make protein E. There are m0lecules called cadherins, a unique combination of which specify each region of the brain. If you made expression of A/B/C/D dependent on whether these cadherins are expressed, you could express D (i.e. any protein you want) within that brain region.
You could figure out which gene to add and where by using more traditional means of genetic engineering that don’t pass on in the germ line.
One potential candidate is just destroying the amygdala. There’s a case study of a woman called SM who had no amygdala. She was really happy and carefree, kinda dumb and reckless but not massively so.
I proposed this to a world expert on cadherins and he liked the idea and he agreed to let me do my my MSci project on something related, but he had no relevant expertise on animal welfare or genetic engineering and I suck at lab work so I turned him down.
If anyone’s interested I’ll share a little infographic I made on the idea
Thanks! I’d love to see the infographic.