Ah, I see. I think the two arguments I’d give here:
Founding 1DaySooner for malaria 5-10 years earlier is high-EV and plausibly very cheap; and there are probably another half-dozen things in this reference class.
We’d need to know much more about the specific interventions in that reference class to confidently judge that we made a mistake. But IMO if everyone in 2015-EA had explicitly agreed “vaccines will plausibly dramatically slash malaria rates within 10 years” then I do think we’d have done much more work to evaluate that reference class. Not having done that work can be an ex-ante mistake even if it turns out it wasn’t an ex-post mistake.
Ah, I see. I think the two arguments I’d give here:
Founding 1DaySooner for malaria 5-10 years earlier is high-EV and plausibly very cheap; and there are probably another half-dozen things in this reference class.
We’d need to know much more about the specific interventions in that reference class to confidently judge that we made a mistake. But IMO if everyone in 2015-EA had explicitly agreed “vaccines will plausibly dramatically slash malaria rates within 10 years” then I do think we’d have done much more work to evaluate that reference class. Not having done that work can be an ex-ante mistake even if it turns out it wasn’t an ex-post mistake.