Thanks MHR. I agree that one shouldn’t need to insist on statistical significance, but if GiveWell thinks that the actual expected effect is ~12% of the MK result, then I think if you’re updating on a similarly-to-MK-powered trial, you’re almost to the point of updating on a coinflip because of how underpowered you are to detect the expected effect.
I agree it would be useful to do this in a more formal bayesian framework which accurately characterizes the GW priors. It wouldn’t surprise me if one of the conclusions was that I’m misinterpreting GiveWell’s current views, or that it’s hard to articulate a formal prior that gets you from the MK results to GiveWell’s current views.
I enjoyed the book and recommend it to others!
In case of of interest to EA forum folks, I wrote a long tweet thread with more substance on what I learned from it and remaining questions I have here: https://twitter.com/albrgr/status/1559570635390562305