So the project is not looking to target the genes that code for egg-laying. We are testing regulatory sequences for their ability to selectively suppress the expression of the gene DMRT1 in gonadal tissue, resulting in the development of ovaries instead of testes. In other words, we are causing male-to-female sex reversal by targeting a single gene: DMRT1. There is the possibility, however, that a gene on the W chromosome either promotes ovary development or ovulation. We do not know this for certain.
The genetics of eggshell colour hasn’t fully been elucidated. It involves several pigments and enzymes but the genes encoding them haven’t been functionally tested and it’s still uncertain how the pigments are synthesized, transported etc. So I think this approach would be very cumbersome and challenging.
But I do agree, pursing a more straightforward solution will have the greatest chances of success.
Dear Effective Altruism community,
It is my great pleasure to announce that this project has been fully funded.
A huge thank you to everybody who backed, shared, and showed interest!
If you are interested in following the developments/findings of the project, I will be posting lab notes on Experiment’s platform (link: here).