Emanuele, is your work on LEV considering how to prioritise research on the different hallmarks of aging? I alluded to that in my previous comment about how to prioritise aging research for short term impact, but given your original post summary indicates that moving LEV closer by 1 year provides 36,500,000 people 1000 QALYs each, this does seem to be a fairly important consideration.
Yes! What Hallmarks to prioritise is an extremely important thing to figure out. The next post is coming out soon, and this topic is a central part of it. In short, I think we should keep an eye on two things when trying to prioritise in this area: if a given research is necessary for achieving LEV, and how neglected it is. Neglectedness seems to be particularly important because the hardest research is often the most neglected (too long term for private investment, too risky for public funding). The hardest hallmarks will be cracked later, so they will more or less constitute the lat “bastions” before LEV. If we speed up progress on them, then we should impact the date of LEV the most. A way to measure neglectedness could be to browse papers by keyword and see what hallmarks have the least number of entries. Another useful preliminary tool could be this roadmap, by lifespan.io. The most neglected/hardest hallmarks are probably the ones currently in the earliest stages of research.
The fact that no new hallmark has been discovered in decades is probably telling. But I think it is reasonable to believe that there are different hallmarks that will be visible in longer-than-human lifespans.
A lot of hallmarks (eg genetic mosaicism or improper stoichiometry or proteins not doing what they’re “supposed to do”) are systems effects rather than effects that can be analyzed reductionistically. Fedichev and Gladyshev have lots of papers that hint in that direction
Emanuele, is your work on LEV considering how to prioritise research on the different hallmarks of aging? I alluded to that in my previous comment about how to prioritise aging research for short term impact, but given your original post summary indicates that moving LEV closer by 1 year provides 36,500,000 people 1000 QALYs each, this does seem to be a fairly important consideration.
Yes! What Hallmarks to prioritise is an extremely important thing to figure out. The next post is coming out soon, and this topic is a central part of it. In short, I think we should keep an eye on two things when trying to prioritise in this area: if a given research is necessary for achieving LEV, and how neglected it is. Neglectedness seems to be particularly important because the hardest research is often the most neglected (too long term for private investment, too risky for public funding). The hardest hallmarks will be cracked later, so they will more or less constitute the lat “bastions” before LEV. If we speed up progress on them, then we should impact the date of LEV the most. A way to measure neglectedness could be to browse papers by keyword and see what hallmarks have the least number of entries. Another useful preliminary tool could be this roadmap, by lifespan.io. The most neglected/hardest hallmarks are probably the ones currently in the earliest stages of research.
To step back even earlier in the research pipeline, do you have any idea if there could be additional hallmarks to be found?
I look forward to the next post!
The fact that no new hallmark has been discovered in decades is probably telling. But I think it is reasonable to believe that there are different hallmarks that will be visible in longer-than-human lifespans.
A lot of hallmarks (eg genetic mosaicism or improper stoichiometry or proteins not doing what they’re “supposed to do”) are systems effects rather than effects that can be analyzed reductionistically. Fedichev and Gladyshev have lots of papers that hint in that direction