I would argue against the interpretation that the SSB-ASB evidence is evidence against the glycemic pathway: (a) as you and the authors note, controlling for adiposity is hard; and (b) even assuming the control was perfect, the fact that post-control, SSBs see a 13% greater incidence for diabetes and ASBs see a 8% greater incidence for diabetes doesn’t contradict the idea that sugar in itself is a significant risk factor via the glycemic pathway—hence (at the very least) the 5% delta, even assuming that the remaining 8% is explained by something that is common to both SSBs/ASBs (doubtful; again, probability just adiposity).
Separately, I would again emphasize the evidence for the glycemic pathway from other studies looking at insulin resistance—which gives us a much clearer sense of the biochemical/physiological basis of the effect.
I think the delta would be lower if they controlled for fat intake. Have you found studies controlling for both adiposity and fat intake?
Separately, I would again emphasize the evidence for the glycemic pathway from other studies looking at insulin resistance—which gives us a much clearer sense of the biochemical/physiological basis of the effect.
Could you link to the main studies informing your views here?
I would argue against the interpretation that the SSB-ASB evidence is evidence against the glycemic pathway: (a) as you and the authors note, controlling for adiposity is hard; and (b) even assuming the control was perfect, the fact that post-control, SSBs see a 13% greater incidence for diabetes and ASBs see a 8% greater incidence for diabetes doesn’t contradict the idea that sugar in itself is a significant risk factor via the glycemic pathway—hence (at the very least) the 5% delta, even assuming that the remaining 8% is explained by something that is common to both SSBs/ASBs (doubtful; again, probability just adiposity).
Separately, I would again emphasize the evidence for the glycemic pathway from other studies looking at insulin resistance—which gives us a much clearer sense of the biochemical/physiological basis of the effect.
I think the delta would be lower if they controlled for fat intake. Have you found studies controlling for both adiposity and fat intake?
Could you link to the main studies informing your views here?