Strong upvoted, I found this very interesting and I expect that quite a few people will find it helpful.
I don’t know if it’s been posted here before, but Scott Alexander has a detailed writeup on depression treatment that people may also find useful, including information on the order he often has his patients try medications in.
Most patients will want either escitalopram or bupropion as first-line treatment. These medications are easy to use and have fewer side effects than most others.
...
[V]ortioxetine [is] very expensive without having obvious advantages over much cheaper drugs, and I can rarely find a use for [it].
Speaking as a vortioxetine user, the main advantage for me is that it has a quite different side effect profile from other antidepressants of similar effect size and “risk level”—one which I personally prefer to SSRIs, bupropion, or mirtazapine.
Strong upvoted, I found this very interesting and I expect that quite a few people will find it helpful.
I don’t know if it’s been posted here before, but Scott Alexander has a detailed writeup on depression treatment that people may also find useful, including information on the order he often has his patients try medications in.
Highlights from the linked writeup:
Speaking as a vortioxetine user, the main advantage for me is that it has a quite different side effect profile from other antidepressants of similar effect size and “risk level”—one which I personally prefer to SSRIs, bupropion, or mirtazapine.