Most patients will want either escitalopram or bupropion as first-line treatment. These medications are easy to use and have fewer side effects than most others.
...
[V]ortioxetine [is] very expensive without having obvious advantages over much cheaper drugs, and I can rarely find a use for [it].
Speaking as a vortioxetine user, the main advantage for me is that it has a quite different side effect profile from other antidepressants of similar effect size and “risk level”—one which I personally prefer to SSRIs, bupropion, or mirtazapine.
Highlights from the linked writeup:
Speaking as a vortioxetine user, the main advantage for me is that it has a quite different side effect profile from other antidepressants of similar effect size and “risk level”—one which I personally prefer to SSRIs, bupropion, or mirtazapine.