Type 2 Diabetes, caused by insulin resistance, is one of the top 10 causes of disability (DALYs) and also is root cause for ischemic heart disease and stroke, which are also in the top 10. People with diabetes are immune compromised and have worse outcomes from infection (as we saw in Covid). Several treatments to reverse diabetes are known, and there are groups like Virta Health doing good work in this space, but some treatments are prohibitively expensive (like GLP-1 agonists). Prevention and nutrition education is underfunded, especially when compared to the health care costs of treating complications like amputations, and dementia.
Due to the use of fructose and other poor quality food, Type 2 diabetes is increasing in both the developed and developing world. Right now, there’s a major shortage of insulin in Ukraine. It is estimated that 95% of people with diabetes are Type 2, if we could prevent a significant fraction of that disease, the insulin could be used for the 0.55% of the population (US) that can’t make endogenous insulin because of Type 1 diabetes.
From a longevity/biotech view, people with type 2 diabetes are much less likely to benefit from future interventions due to poor health of tissues.
(Disclosure—I’m a physician specializing in disability and diabetes is my nemesis)
Inspired by this proposal, researching the claim that seed oils may be responsible for many “diseases of civilization” (contamination theory of obesity). Probably(?) not true but highly important and actionable if true.
Yes, I am very pro-fasting (not medical advice, just opinion). The Obesity Code by Jason Fung is a really good description of why this works and I have given copies to colleagues to convince them. People often need support to start fasting—I have a dream of a retreat with these supports, like bone broth.
Solve Type 2 Diabetes
Biorisk and Recovery from Catastrophe
Type 2 Diabetes, caused by insulin resistance, is one of the top 10 causes of disability (DALYs) and also is root cause for ischemic heart disease and stroke, which are also in the top 10. People with diabetes are immune compromised and have worse outcomes from infection (as we saw in Covid). Several treatments to reverse diabetes are known, and there are groups like Virta Health doing good work in this space, but some treatments are prohibitively expensive (like GLP-1 agonists). Prevention and nutrition education is underfunded, especially when compared to the health care costs of treating complications like amputations, and dementia.
Due to the use of fructose and other poor quality food, Type 2 diabetes is increasing in both the developed and developing world. Right now, there’s a major shortage of insulin in Ukraine. It is estimated that 95% of people with diabetes are Type 2, if we could prevent a significant fraction of that disease, the insulin could be used for the 0.55% of the population (US) that can’t make endogenous insulin because of Type 1 diabetes.
From a longevity/biotech view, people with type 2 diabetes are much less likely to benefit from future interventions due to poor health of tissues.
(Disclosure—I’m a physician specializing in disability and diabetes is my nemesis)
Inspired by this proposal, researching the claim that seed oils may be responsible for many “diseases of civilization” (contamination theory of obesity). Probably(?) not true but highly important and actionable if true.
How about treating diabetes with fasting?
I know many people who used fasting to cure diabetes..
Yes, I am very pro-fasting (not medical advice, just opinion). The Obesity Code by Jason Fung is a really good description of why this works and I have given copies to colleagues to convince them. People often need support to start fasting—I have a dream of a retreat with these supports, like bone broth.