So for example rabies has a ~100% fatality rate without vaccination, but immune systems are expressive enough to produce antibodies with vaccination.
I’m not personally convinced by directly empirical evidence that it hasn’t happened so far → this isn’t possible, since the space of pathogens that’s evolutionarily plausible is presumably a lot narrower than the space of possible pathogens, including engineered ones.
Interesting though not super important piece of information: Rabies is ~100% fatal once symptoms present, but there is evidence that even without vaccination, some humans have been exposed and survived, they just didn’t realize it.
So for example rabies has a ~100% fatality rate without vaccination, but immune systems are expressive enough to produce antibodies with vaccination.
I’m not personally convinced by directly empirical evidence that it hasn’t happened so far → this isn’t possible, since the space of pathogens that’s evolutionarily plausible is presumably a lot narrower than the space of possible pathogens, including engineered ones.
Interesting though not super important piece of information: Rabies is ~100% fatal once symptoms present, but there is evidence that even without vaccination, some humans have been exposed and survived, they just didn’t realize it.