Definitely not expert enough to confidently answer this, but I thought the answer was obviously yes—I don’t think there are any diseases where it doesn’t happen as a natural part of response. (Even HIV is mostly fought off quickly, but in cases where it spreads, it infects enough immune cells that it persists and eventually destroys the immune system.)
So for example rabies has a ~100% fatality rate without vaccination, but immune systems are expressive enough to produce antibodies with vaccination.
I’m not personally convinced by directly empirical evidence that it hasn’t happened so far → this isn’t possible, since the space of pathogens that’s evolutionarily plausible is presumably a lot narrower than the space of possible pathogens, including engineered ones.
Interesting though not super important piece of information: Rabies is ~100% fatal once symptoms present, but there is evidence that even without vaccination, some humans have been exposed and survived, they just didn’t realize it.
Definitely not expert enough to confidently answer this, but I thought the answer was obviously yes—I don’t think there are any diseases where it doesn’t happen as a natural part of response. (Even HIV is mostly fought off quickly, but in cases where it spreads, it infects enough immune cells that it persists and eventually destroys the immune system.)
So for example rabies has a ~100% fatality rate without vaccination, but immune systems are expressive enough to produce antibodies with vaccination.
I’m not personally convinced by directly empirical evidence that it hasn’t happened so far → this isn’t possible, since the space of pathogens that’s evolutionarily plausible is presumably a lot narrower than the space of possible pathogens, including engineered ones.
Interesting though not super important piece of information: Rabies is ~100% fatal once symptoms present, but there is evidence that even without vaccination, some humans have been exposed and survived, they just didn’t realize it.