Yep for sure—and with something like a 50% chance of success in phase 3 trials, the chance of it working are pretty good!
Those looking through an AMR lens could even argue that slowing down the proliferation of MDR/​XDR TB could be the most important outcome from a vaccine like this—potentially more than direct lives saved through preventing the disease directly.
XDRTB has been an interesting one, obviously its a terrifying prospect, but it hasn’t proliferated as much as I think we expected 10-15 years ago. When I did my tropical med diploma it was all the buzz, we feared it would spread from Russian prisons around the world within 10 years and leave millions with no options for treatment. Although it continues to spread, fortunately the proportion of patients with XDR hasn’t increased as we thought it might, and in many cases has even reduced due to better treatment programs.
Saving someone a google search hopefully: XDRTB = Extensively drug-resistant tuberculosis MDRTB = Multi drug-resistant tuberculosis
Seems like it’s my week of learning a bit about tuberculosis! What’s up with the acronyms in the tuberculosis-space anyways? TB isn’t that much shorter than tuberculosis.
The search function could be a little more sensitive, but otherwise it’s a good resource. I also wish I knew the reasoning behind using all these acronyms. Maybe it’s just by virtue of its age, being isolated in 1882 -- 142 years is a lot of time to accrue terminology...
This would be massive if successful, and one of the few ways around XDRTB (and should contribute to slowing drug resistance more generally).
Yep for sure—and with something like a 50% chance of success in phase 3 trials, the chance of it working are pretty good!
Those looking through an AMR lens could even argue that slowing down the proliferation of MDR/​XDR TB could be the most important outcome from a vaccine like this—potentially more than direct lives saved through preventing the disease directly.
XDRTB has been an interesting one, obviously its a terrifying prospect, but it hasn’t proliferated as much as I think we expected 10-15 years ago. When I did my tropical med diploma it was all the buzz, we feared it would spread from Russian prisons around the world within 10 years and leave millions with no options for treatment. Although it continues to spread, fortunately the proportion of patients with XDR hasn’t increased as we thought it might, and in many cases has even reduced due to better treatment programs.
For example here showed a massive reduction in Southern India https://​​www.nature.com/​​articles/​​s41598-020-74432-y
Saving someone a google search hopefully:
XDRTB = Extensively drug-resistant tuberculosis
MDRTB = Multi drug-resistant tuberculosis
Seems like it’s my week of learning a bit about tuberculosis! What’s up with the acronyms in the tuberculosis-space anyways? TB isn’t that much shorter than tuberculosis.
The Global TB Dictionary has been released ahead of World TB Day 2024: https://​​tbdictionary.org/​​
The search function could be a little more sensitive, but otherwise it’s a good resource. I also wish I knew the reasoning behind using all these acronyms. Maybe it’s just by virtue of its age, being isolated in 1882 -- 142 years is a lot of time to accrue terminology...