Thank you. I certainly agree that in most occupations (operating large machinery, doing difficult cognitive tasks) and studying, it is not of benefit to feel high on the job. However, I would note important to note that 1) partial opioid agonists have significantly more mild euphoriant properties than full agonists and 2) Kratom, which contains a partial mu-opioid agonist, has traditionally been used in Southeast Asia by field laborers as a ‘labor enhancement’ to enjoy their work more and combat their pain problems (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657101/). For individuals who spend the majority of their lives in grueling conditions and who appear to be facilitated rather than harmed by the effects of partial agonist opioids, I see more benefit than harm to having a slightly euphoria-inducing agent. For other occupations, this makes less sense.