Alfredo Parra 🔸

• Alfredo Parra 🔸Feb 19, 2025, 1:48 PM

  4 points

  2 ∶ 0

  in reply to: Hasan 🔸’s comment on: The Quest for a Stone-Free World: Chanca Pie­dra (Phyl­lan­thus niruri) as an Acute and Pro­phy­lac­tic Treat­ment for Kid­ney Stones and Their As­so­ci­ated Ex­treme Nega­tive Valence

  Thanks, Hasan! :)

  Obviously I want to be cautious about making such a recommendation. 😅 But I’m confident enough in our data (pointing at chanca piedra being safer than e.g. melatonin) that I myself take 500mg once a week, but mostly because (a) that was the default recommended dosage on the bottle I got, and (b) I thought taking it daily would be an overkill given that I think I’m at very low risk. But I could see the rationale for taking it daily for one month per year, as you suggest. Or maybe doing both?

• Alfredo Parra 🔸Feb 19, 2025, 1:26 PM

  12 points

  3 ∶ 0

  in reply to: Henry Howard🔸’s comment on: The Quest for a Stone-Free World: Chanca Pie­dra (Phyl­lan­thus niruri) as an Acute and Pro­phy­lac­tic Treat­ment for Kid­ney Stones and Their As­so­ci­ated Ex­treme Nega­tive Valence

  Thanks, Henry. Your care, as a doctor, for people’s wellbeing shines through! We’d also hate to learn that this herb causes e.g. delayed, severe side effects. We hope this question can be settled for good asap given the scope and severity of the suffering involved here!

  We start our post acknowledging that online reviews are not usually a reliable source of information concerning medical matters. So we asked ourselves: if there was a statistically significant signal, how could we possibly find it? This is what motivated us to:

  • Compare reviews across three different platforms (WebMD, Amazon, Reddit).

  • Compare reviews of chanca piedra to reviews of other kidney stone treatments within those same platforms.

  • Compare reviews of other popular supplements within those same platforms (e.g., ashwagandha, melatonin).

  • Do sub-analyses of the data, e.g. looking only at the most credible reviews and reading closely any reviews mentioning any severe or rare side effects (which we report).

  • Look into whatever literature we could find about chanca piedra to see if mechanistic explanations were compatible with our findings.

  Would an analysis of Reddit and Amazon reviews of thalidomide have revealed its negative effects? Bex powder? Diethylstilbestrol? Betel nut?

  Not necessarily, no. But if we had access to thousands of anecdotes and reviews of these medications dating back to 2008, including by people who have taken them for years, the chances would go up significantly. I guess that’s our main “selling point”.

  In the end, our goal is to reduce as much extreme suffering as possible. If it turns out that taking chanca piedra actually increases extreme suffering, we’d want to be the first ones to know! But from what we can tell, that hypothesis is looking very unlikely.

• Alfredo Parra 🔸Feb 19, 2025, 11:53 AM

  1 point

  0 ∶ 0

  in reply to: tobycrisford 🔸’s comment on: Indi­rect re­al­ism illus­trated (and why it mat­ters so much for con­scious­ness de­bates)

  I really appreciate your feedback and your questions! 🙏

  I’d love to reply in detail but it would take me a while. 😅 But maybe two quick points:

  1. On observer independence: The main challenge that computational functionalism faces (IMO) is that there’s no principled way to say “THIS is the (observer-independent) system I posit to be conscious” because algorithms, simulations, etc. don’t have clearly-defined boundaries. It’s up to us (as conscious agents) to arbitrarily determine those boundaries, so anything goes! The section “Is simulation an intrinsic property?” in this post sums it up quite neatly, I think. Field topology, as well as, say, entanglement networks, do give us observer-independent boundaries.

  2. On the simulation behaving identically to the brain: Here I think one could reasonably ask: What if, in order for the simulation to behave identically, we had to simulate the brain even at the smallest physical scale? Many people think this isn’t necessary and that the “neuron as digital switches” abstraction is enough. But say we actually had to simulate EM field phenomena, quantum phenomena, etc. Then I think runtime complexity matters, since maybe some parts of the brain can be simulated easily and others take millions of years. Can one bootstrap a coherent simulation from that? Now imagine trying to simulate multiple brains interacting with each other, running physics experiments, etc. Can one set up the simulation such that e.g. they all measure the speed of light to be the same? Or otherwise always get the same experimental results? I kind of doubt so. But regardless, the previous point about observer dependence would still stand.

• Alfredo Parra 🔸Feb 19, 2025, 11:10 AM

  3 points

  2 ∶ 0

  in reply to: Joseph’s comment on: The Quest for a Stone-Free World: Chanca Pie­dra (Phyl­lan­thus niruri) as an Acute and Pro­phy­lac­tic Treat­ment for Kid­ney Stones and Their As­so­ci­ated Ex­treme Nega­tive Valence

  Thanks for your questions, Joseph!

  Would it be easier to convince lots of people to buy and consume chanca piedra than to convince lots of people to drink an extra liter of water each day? Any thoughts comparing the relative impact and tractability of these two paths? I’m particularly thinking of patient compliance and of the fad/​popularity of large water bottles in recent years.

  We’ve also been wondering about that. I drink a lot of water myself but I tend to forget how much of a hassle it can be for a lot of people who are not used to drinking much water. Other conditions face similar trade-offs. For example, experts might insist that exercising 30 minutes per day is among the most helpful interventions against depression, yet many people would understandably much rather take a pill. The same goes for weight loss or other interventions that require lifestyle changes. Urologists have been recommending increasing water intake for decades, yet incidence keeps growing. Intuitively, it feels more tractable to test the effectiveness of chanca piedra through a large RCT and (if it works) have urologists adopt it as part of their standard recommendations than running global awareness campaigns to drink more water. But I admit I haven’t done a BOTEC.

  Have you spoken with a doctor or medical researcher specializing in kidney stones about this?

  Not yet! But, as part of our next steps, we plan to use this writeup to reach out to experts.

  Considerations regarding the distribution of pain?

  We haven’t looked into the distribution in detail (and there’s not much data, unfortunately), but we currently think that the median case is likely still very painful. For example, the American Urological Association states:

  The classic presentation of a renal stone is acute, colicky flank pain radiating to the groin or scrotum, often associated with nausea and vomiting. […] Renal and ureteral colic are often considered the most severe pain ever experienced by patients, and many female stone patients describe the pain as even more intense than that of childbirth.

  In this survey, the mean (!) score of kidney stone pain (6.9/​10, n=239) was only slightly lower than that of labor pain (7.2/​10, n=308) with similar error bars. I think that this is more consistent with a story of the median stone being very painful (than with a story where, say, most stones are only mildly painful). In this (much smaller) survey, ⁹⁄₉₃ people mentioned kidney stones to be among their top 3 most painful experiences ever, in line with the ~10% lifetime prevalence. “In other words, there is reason to believe that a large fraction of the people who have had [kidney stones] will rate them as one of their top 3 most painful experiences.” Neither of these two surveys selected for e.g. patients seeking medical treatment for stones (as is usually the case in the kidney stone literature).

  It’s also worth keeping in mind that people who get kidney stones (including small, asymptomatic ones) are at a higher risk of getting stones later on.

  I hope this helps! :)

• Alfredo Parra 🔸Feb 19, 2025, 8:43 AM

  9 points

  1 ∶ 0

  in reply to: Henry Howard🔸’s comment on: The Quest for a Stone-Free World: Chanca Pie­dra (Phyl­lan­thus niruri) as an Acute and Pro­phy­lac­tic Treat­ment for Kid­ney Stones and Their As­so­ci­ated Ex­treme Nega­tive Valence

  Thank you for your feedback, Henry! :)

  We’d absolutely love there to be RCTs and definitely encourage larger studies to be run (as mentioned in the Final Recommendations section). It seems like such low-hanging fruit. And one of the main motivations behind this project is that it becomes exactly that incentive needed to get those studies running.

  At the same time, it could be years until a large RCT is run. Given the rising incidence of kidney stones worldwide, it seems like asking people to drink more water and eat low-oxalate foods isn’t cutting it.

  We wrote “Cautiously consider taking chanca piedra yourself” as our very last recommendation. We wanted to strike a balance between recommending something for which large RCTs are still missing and acknowledging that the suffering involved can be so severe that some action could be warranted (especially given that, as we emphasize, chanca piedra seems to cause fewer side effects than e.g. melatonin and ashwagandha).

The Quest for a Stone-Free World: Chanca Pie­dra (Phyl­lan­thus niruri) as an Acute and Pro­phy­lac­tic Treat­ment for Kid­ney Stones and Their As­so­ci­ated Ex­treme Nega­tive Valence

• Alfredo Parra 🔸Feb 17, 2025, 9:17 PM

  3 points

  0 ∶ 0

  in reply to: tobycrisford 🔸’s comment on: Indi­rect re­al­ism illus­trated (and why it mat­ters so much for con­scious­ness de­bates)

  Thanks, and sorry, I could have been more precise there. I guess I was thinking of the fact that, for example, some quantum systems would take, I don’t know, the age of the universe to compute on a digital computer. And as I hinted in my previous response, the runtime complexity matters. I illustrated this point in a previous post, using the example of an optical setup used to compute Fourier transforms at the speed of light, which you might find interesting. Curious if you have any thoughts!

• Alfredo Parra 🔸Feb 17, 2025, 8:52 AM

  5 points

  2 ∶ 0

  in reply to: tobycrisford 🔸’s comment on: Indi­rect re­al­ism illus­trated (and why it mat­ters so much for con­scious­ness de­bates)

  Thank you so much for your questions! :) Some quick thoughts:

  If the human brain operates according to the known laws of physics, then in principle we could simulate it on a modern computer, and it would behave identically to the real thing (i.e. would respond in the same way to the same stimuli, and claim to see a purple ball with grandma’s face on it if given simulated LSD).

  The brain operating according to the known laws of physics doesn’t imply we can simulate it on a modern computer (assuming you mean a digital computer). A trivial example is certain quantum phenomena. Digital hardware doesn’t cut it. And even if you do manage to simulate certain parts of the system, the only way to get it to behave identically to the real thing is to use the real thing as the substrate. For example, sure, you can crudely simulate the propagation of light on a digital computer, but in order for it to behave identically to the real thing, you’d have to ensure e.g. that all “observers” within your simulation measure its propagation speed to be c. I don’t believe you can do that given the costs of embodiment of computers.

  Would such a brain simulation have qualia according to your view? Yes, no, or you don’t think the brain operates according to known laws of physics?

  It would be trivial “qualia dust,” like most electromagnetic phenomena (which are not globally bound). (I do think that the brain operates according to the laws of physics.)

  If (1) is answered no, what would happen if you gradually replaced a biological brain with a simulated brain bit by bit, replacing sections of the cells one at a time with a machine running a simulation of its counterpart? What would that feel like for the person? Their consciousness would slowly be disappearing but they would not outwardly behave any differently, which seems very odd.

  I think “gradually replacing the biological brain with a simulated brain bit by bit” begs the question. For example, what would it mean to replace a laser beam “bit by bit”?

  If (1) is answered yes, does that mean that whatever this strange property of the EM field is, it will necessarily be possessed by the inner workings of the computer as well, when this simulation is run?

  Just to be clear, I’m not claiming that the EM field has some additional strange property, but rather that the EM field as it is is conscious (cf. dual-aspect monism). Also consider: When you talk about “the simulation being run,” where exactly is the simulation? In the chips? In sub-elements of the chips? On the computer screen? Simulations, algorithms, etc. don’t have clearly-delineated boundaries, unlike our conscious experience. This is a problem.

  If all the fields of physics are made of qualia, then everything is made of qualia, including the electron field, the quark fields, etc?

  I believe that to be the most parsimonious and consistent view, yes.

Indi­rect re­al­ism illus­trated (and why it mat­ters so much for con­scious­ness de­bates)

• Alfredo Parra 🔸Feb 7, 2025, 11:43 AM

  3 points

  0 ∶ 0

  in reply to: Lizka’s comment on: Lizka’s Shortform

  @Lucius Caviola has also written about this topic, e.g. Will disagreement about AI rights lead to societal conflict?

  And my two cents on why I don’t think we should worry about digital sentience (plus the slicing problem). :)

• Alfredo Parra 🔸Dec 26, 2024, 9:45 AM

  2 points

  0 ∶ 0

  on: Dona­tion Cel­e­bra­tion Post

  Qualia Research Institute, plus some pro bono time for a project at the intersection of law and AI.

• Alfredo Parra 🔸Dec 9, 2024, 6:30 PM

  3 points

  0 ∶ 0

  in reply to: Toby Tremlett🔹’s comment on: My cur­rent takes on AI Welfare

  I get what you mean! Here are a few very quick thoughts—hope they make sense!

  • Maybe one challenge around introspecting on binding is that one typically has to be in altered or ill states of consciousness to experience what it’s like for binding to break down. For instance, under some psychedelics, the color of an object can “bleed out” of its boundaries.

  • In normal waking consciousness, we just take binding for granted. We have no problem recognizing that the eyes, nose, mouth, etc. of the person in front of us are “glued” together into a unified gestalt that we can make sense of (and e.g. recognize as our friend). Some people with integrative agnosia can’t do that.

  • As David Pearce says, no binding = no mind. Without binding, there would only be “qualia dust” floating around. It makes sense that evolution would recruit bound experiences to make sense of the external world. Ethically, we should care about bound experiences.

  • Binding is also the reason why you can’t do your taxes on a high dose of LSD (though maybe altered states of consciousness can be used for other types of computation).

  Happy to chat about this more in person one of these days! I just moved to London and plan to visit Oxford every now and then. ☺️

• Alfredo Parra 🔸Dec 9, 2024, 4:19 PM

  1 point

  0 ∶ 0

  on: My cur­rent takes on AI Welfare

  Thanks for sharing your thoughts!

  I’m unsure whether we can in principle ascertain whether a digital mind is conscious.

  I used to believe this too, but I’ve actually become quite optimistic that this is a tractable question. If, as David Pearce argues, the laws of physics don’t break down inside the brain, and we define the constraints that a satisfactory theory of consciousness should fulfill, then I believe we can make very good progress. For instance, one such constraint is that the theory should solve the binding problem (see also here). So if we cannot observe a binding mechanism in digital computers, or explain how digital computers could in principle give rise to binding (as I and other at QRI argue), then that should be very strong evidence against digital computers being conscious. More in: Digital Sentience: Can Digital Computers Ever “Wake Up”?

  (Note that this doesn’t rule out other forms of artificial, non-digital consciousness!)

• Alfredo Parra 🔸Dec 9, 2024, 4:04 PM

  1 point

  0 ∶ 0

  on: The Limits of Ar­tifi­cial Con­scious­ness: A Biol­ogy-Based Cri­tique of Chalmers’ Fad­ing Qualia Argument

  Thanks for sharing this! You might be interested in this: Consciousness Isn’t Substrate-Neutral: From Dancing Qualia & Epiphenomena to Topology & Accelerators

• Alfredo Parra 🔸Dec 6, 2024, 3:29 PM

  1 point

  0 ∶ 0

  on: Treat­ing Cluster Headaches Us­ing N,N-DMT and Other Tryptamines

  Leaving this here: “Testimonial of a chronic cluster headache patient after using DMT to abort attacks”. @jonleighton of the Organisation for the Prevention of Intense Suffering interviews John Fletcher, chronic cluster headache patient.

  JF: I’m 65 years old now and they [cluster headaches] started for me in late September 1973, so about 51 years I’ve had cluster headaches. […] I came out of a seven-year remission and as soon as I did, I haven’t had a break since, and that was 6 months ago. I’ve been getting at least 10 attacks a day, every day.

  JL: Can you tell us a little bit more about the other medical conditions that you’re suffering from at the moment, just to give a bit of context?

  JF: Besides stage five COPD [chronic obstructive pulmonary disease], I have adenocarcinoma lung cancer. I have achalasia disease, which my esophagus swells up and ultimately causes me to aspirate food and causes bacterial pneumonia. And I’ve got multiple abdominal hernias from surgery. I had 20 major surgeries. I broke my back at the beginning of the year that was caused by severe osteoporosis from steroids, from my COPD. And I’ve broken my ribs 30 or 40 times in the last couple of years from severe osteoporosis.

  JL: How would you compare the suffering due to cluster headaches compared to everything else that you’re experiencing?

  JF: I wouldn’t trade anything for cluster headaches. None of it. Cluster headaches is the worst pain I’ve ever had in my life. I’ve never felt anything worse. And, I mean, including being terminally ill and breaking and just so many other really severe painful conditions, but cluster headaches is in a category by itself. I’ve never felt anything like it. It’s such severe pain, it’s literally violent screaming pain and, to put it bluntly, it feels like you’re being murdered. It’s unbelievable pain. And you expect to see blood. Telling people about my first attack, I thought I was shot in the head. I thought somebody shot me and I was dying. Every attack pretty much feels like you’re dying. It’s just horrible, horrible thing. So no, I wouldn’t trade any of it for cluster headaches.

  JL: And what medications have you tried? And have any of them worked for you over the years?

  …

• Alfredo Parra 🔸Nov 9, 2024, 9:11 PM

  1 point

  0 ∶ 0

  in reply to: Deborah W.A. Foulkes’s comment on: Quan­tify­ing the Global Bur­den of Ex­treme Pain from Cluster Headaches

  Thanks for sharing, Deborah! I’ll add these resources to my list of interventions. :)

• Alfredo Parra 🔸Nov 8, 2024, 4:29 PM

  3 points

  0 ∶ 0

  in reply to: saulius’s comment on: saulius’s Shortform

  I’m very interested in what you find out! It’d be great to compare the results of the survey with the predictions of the heavy-tailed valence hypothesis (see here or here).

• Alfredo Parra 🔸Nov 8, 2024, 3:57 PM

  3 points

  1 ∶ 0

  in reply to: Marius L T’s comment on: Quan­tify­ing the Global Bur­den of Ex­treme Pain from Cluster Headaches

  Thanks so much for your comment!

  Actually, someone else brought up this point separately, so I agree there’s more to say here. I’d love to dig deeper into this question and possibly write a paper on the topic (e.g. for this collection). If you have literature to recommend (either by you or otherwise), please send it my way. And also let me know if you’d like to get involved in such a project. :)

• Alfredo Parra 🔸Nov 7, 2024, 7:26 AM

  3 points

  0 ∶ 0

  in reply to: Tim Duffy’s comment on: Quan­tify­ing the Global Bur­den of Ex­treme Pain from Cluster Headaches

  Gee, not sure what happened there—thanks for pointing that out! I’ve edited the footnote.

• Alfredo Parra 🔸Nov 6, 2024, 8:07 AM

  3 points

  0 ∶ 0

  in reply to: Tim Duffy’s comment on: Quan­tify­ing the Global Bur­den of Ex­treme Pain from Cluster Headaches

  Thank you for your comment, Tim!

  Indeed, the choice of e is arbitrary and used for illustration purposes. And the base 6 is simply the choice for which the total burden of CH is larger than that of migraines, so it’s also not derived from first principles. This footnote is relevant:

  The resulting scaling as $6^x$ would mean that the 0–10 scale would have to span 4 orders of magnitude. While Gómez-Emilsson & Percy (2023) suggest the scale spans “at least two orders of magnitude”, private communication with the authors indicates their central estimates might be closer to 4 orders of magnitude, with uncertainty ranging from 2 to 8 OOMs.

  The paper cited also mentions the possibility of a linear relationship for lower pain intensities and an exponential relationship at higher intensities (a “kinked” distribution), highlighting the fact that there are more possibilities beyond a uniform exponential increase.

  I personally don’t have a good intuition for what the base should be but might do more work on this specific question.

  I’m also not sure what the optimal mapping of intensities for the Russell vs Torelli & Manzoni scales is, also considering the fact that the two studies had different methodologies. I think there’s no correct answer, so that was my best guess (though I could also imagine “Very slight” being more intense than a 1.5). Do let me know if you have other suggestions! (Or feel free to fork the code and play around with the parameters. :) )