Barry Grimes

• Barry Grimes 23 Sep 2024 16:27 UTC

  2 points

  2 ∶ 0

  in reply to: Toby Tremlett🔹’s comment on: An­nounc­ing An­i­mal Welfare vs Global Health De­bate Week (Oct 7-13)

  Maybe you should have a separate debate week on the most appropriate name for the “global health” cause area ;o)

• Barry Grimes 23 Sep 2024 16:16 UTC

  4 points

  1 ∶ 0

  in reply to: Toby Tremlett🔹’s comment on: An­nounc­ing An­i­mal Welfare vs Global Health De­bate Week (Oct 7-13)

  Thanks Toby! Health is part of wellbeing, so “global wellbeing” would be sufficient.
  
  However, it’s worth noting that “global wellbeing” should apply to all moral patients, whereas “global health” is usually understood as a human-specific set of interventions.

• Barry Grimes 23 Sep 2024 12:23 UTC

  9 points

  4 ∶ 1

  on: An­nounc­ing An­i­mal Welfare vs Global Health De­bate Week (Oct 7-13)

  It would be better to call this: Animal Welfare vs Human Welfare Debate Week
  
  When your scope extends to “any intervention which primarily aims to increase the wellbeing of animals, or decrease their suffering, and...the same for humans”, the term “global health” only represents a sub-set of possible interventions.

Sub­mit a chap­ter pro­posal for the 2025 World Hap­piness Report

• Barry Grimes 8 Feb 2024 10:36 UTC

  20 points

  1 ∶ 0

  on: Self-guided men­tal health apps aren’t cost-effec­tive… yet

  Welcome to the forum! Thanks so much for taking the time to dig into this question and sharing your findings. The treatment gap in global mental health is enormous and apps are an essential tool for addressing this challenge.

  I didn’t have time to review your calculations in detail, but I have a few general reflections that may be useful.
  
  1) There is a brand new meta-analysis on the efficacy of mental health apps which includes 176 RCTS (Linardon et al, 2024). They conclude that “apps have overall small but significant effects on symptoms of depression and generalized anxiety, and that specific features of apps – such as CBT or mood monitoring features and chatbot technology – are associated with larger effect sizes.”
  
  2) There is a substantial difference in efficacy between self-help and guided self-help apps. Kaya Guides (incubated by Charity Entrepreneurship) is using WhatsApp to pilot the WHO’s guided self-help intervention in India. Their founder wrote an excellent summary of their work here.
  
  3) Be careful with using a single WELLBY number for AMF. The wellbeing effects of life-extending interventions vary widely depending on philosophical choices, so it is better to use the range of possible outcomes rather than a single figure (see The Elephant in the Bednet).
  
  4) John Torous is a leading researcher and thought leader in digital mental health. If you’d like to spend more time learning about this topic, I recommend looking at his recent publications.

  5) The current market for mental health apps is completely unregulated and there are major concerns about privacy and data protection. Wellcome recently awarded £1.8m to MHRA and NICE to explore how the market could be regulated more effectively to protect patient safety.

• Barry Grimes 25 Jan 2024 9:22 UTC

  4 points

  0 ∶ 0

  in reply to: sn’s comment on: Men­tal Health Re­port (CEARCH) [Ex­ec­u­tive Sum­mary]

  You may be interested in this recent meta-analysis on the efficacy of mental health apps. The authors conclude that: “apps have overall small but significant effects on symptoms of depression and generalized anxiety, and that specific features of apps – such as CBT or mood monitoring features and chatbot technology – are associated with larger effect sizes.”

• Barry Grimes 8 Jan 2024 13:48 UTC

  11 points

  2 ∶ 0

  on: Whose life mat­ters more—a baby’s or an adult’s?

  I recommend The Elephant in the Bednet as an accessible introduction to the different philosophical theories for the badness of death.

• Barry Grimes 31 Dec 2023 13:42 UTC

  9 points

  1 ∶ 0

  in reply to: Owen Cotton-Barratt’s comment on: Wel­lbe­ing al­ign­ment—pro­posal to The Hap­pier Lives In­sti­tute with fo­cus on sys­temic changes

  This comment helps to highlight the importance of language when discussing this topic. Happiness and wellbeing are not the same thing and it can lead to confusion when the two terms are used interchangeably.

  This post explains the three main theories of wellbeing: hedonism, desire-based views, and objective list views. If you’re a hedonist, then failing to optimise for happiness would be a mistake. However, as Owen points out, people often trade off happiness for other things they value which is more consistent with the objective list theory.

  Over recent decades, the field of wellbeing science has settled on ‘life satisfaction’ as the primary metric for subjective wellbeing. It’s still important to track other measures too (e.g., positive/​negative affect, sense of meaning/​purpose), but I share the view that life satisfaction should be the goal of society.

  That’s because life satisfaction is the common unit that people use when they make trade-offs between happiness, purpose, duty etc. It’s the ‘all things considered’ assessment of a person’s life, according to what they value. Many attempts to measure wellbeing rely on a dashboard of indicators, but in all those cases, the relative weightings of the indicators are decided by the researchers rather than the subjects of the research and, in my view, that misses the whole point. Having said that, I’ve read some compelling arguments against the life satisfaction approach from Plant (2023) and Thoma (2021) which readers may find insightful.

• Barry Grimes 11 Dec 2023 11:19 UTC

  23 points

  5 ∶ 1

  in reply to: Gregory Lewis🔸’s comment on: Talk­ing through de­pres­sion: The cost-effec­tive­ness of psy­chother­apy in LMICs, re­vised and expanded

  I’m feeling confused by these two statements:

  Although there are other problems, those I have repeated here make the recommendations of the report unsafe.

  Even if one still believes the bulk of (appropriate) analysis paths still support a recommendation, this sensitivity should be made transparent.

  The first statement says HLI’s recommendation is unsafe, but the second implies it is reasonable as long as the sensitivity is clearly explained. I’m grateful to Greg for presenting the analysis paths which lead to SM < GD, but it’s unclear to me how much those paths should be weighted compared to all the other paths which lead to SM > GD.
  
  It’s notable that Cuijpers (who has done more than anyone in the field to account for publication bias and risk of bias) is still confident that psychotherapy is effective.
  
  I was also surprised by the use of ‘unsafe’. Less cost-effective maybe, but ‘unsafe’ implies harm and I haven’t seen any evidence to support that claim.

• Barry Grimes 8 Dec 2023 16:36 UTC

  2 points

  0 ∶ 0

  in reply to: Rebecca’s comment on: Talk­ing through de­pres­sion: The cost-effec­tive­ness of psy­chother­apy in LMICs, re­vised and expanded

  Thanks Rebecca. I will delete the duplicates.

• Barry Grimes 8 Dec 2023 10:01 UTC

  11 points

  0 ∶ 0

  in reply to: Jason’s comment on: Talk­ing through de­pres­sion: The cost-effec­tive­ness of psy­chother­apy in LMICs, re­vised and expanded

  I recently discovered that GiveWell decided to exclude an outlier in their water chlorination meta-analysis. I’m not qualified to judge their reasoning, but maybe others with sufficient expertise will weigh in?

  We excluded one RCT that meets our other criteria because we think the results are implausibly high such that we don’t believe they represent the true effect of chlorination interventions (more in footnote).[4] It’s unorthodox to exclude studies for this reason when conducting a meta-analysis, but we chose to do so because we think it gives us an overall estimate that is more likely to represent the true effect size.

• Barry Grimes 8 Dec 2023 9:59 UTC

  0 points

  0 ∶ 0

  in reply to: Jason’s comment on: Talk­ing through de­pres­sion: The cost-effec­tive­ness of psy­chother­apy in LMICs, re­vised and expanded

  I recently discovered that GiveWell decided to exclude an outlier in their water chlorination meta-analysis. I’m not qualified to judge their reasoning, but maybe others with sufficient expertise will weigh in?

  We excluded one RCT that meets our other criteria because we think the results are implausibly high such that we don’t believe they represent the true effect of chlorination interventions (more in footnote).[4] It’s unorthodox to exclude studies for this reason when conducting a meta-analysis, but we chose to do so because we think it gives us an overall estimate that is more likely to represent the true effect size.

• Barry Grimes 6 Dec 2023 12:19 UTC

  21 points

  4 ∶ 1

  in reply to: Burner1989’s comment on: Talk­ing through de­pres­sion: The cost-effec­tive­ness of psy­chother­apy in LMICs, re­vised and expanded

  [Disclaimer: I worked at HLI until March 2023. I now work at the International Alliance of Mental Health Research Funders]

  Gregory says

  these problems are sufficiently major I think potential donors are ill-advised to follow the recommendations and analysis in this report.

  That is a strong claim to make and it requires him to present a convincing case that GiveDirectly is more cost-effective than StrongMinds. I’ve found his previous methodological critiques to be constructive and well-explained. To their credit, HLI has incorporated many of them in the updated analysis. However, in my opinion, the critiques he presents here do not make a convincing case.

  Taking his summary points in turn...

  1. The literature on PT in LMICs is a complete mess. Insofar as more sense can be made from it, the most important factors appear to belong to the studies investigating it (e.g. their size) rather than qualities of the PT interventions themselves.

  I think this is much too strong. The three meta-analyses (and Gregory’s own calculations) give me confidence that psychotherapy in LMICs is effective, although the effects are likely to be small.

  2. Trying to correct the results of a compromised literature is known to be a nightmare. Here, the qualitative evidence for publication bias is compelling. But quantifying what particular value of ‘a lot?’ the correction should be is fraught: numerically, methods here disagree with one another dramatically, and prove highly sensitive to choices on data exclusion.

  There is no consensus on the appropriate methodology for adjusting publication bias. I don’t have an informed opinion on this, but HLI’s approach seems reasonable to me and I think it’s reasonable for Greg to take a different view. From my limited understanding, neither approach makes GiveDirectly more cost-effective.

  3. Regardless of how PT looks in general, StrongMinds, in particular, is looking less and less promising. Although initial studies looked good, they had various methodological weaknesses, and a forthcoming RCT with much higher methodological quality is expected to deliver disappointing results.

  We don’t have any new data on StrongMinds so I’m confused why Greg thinks it’s “less and less promising”. HLI’s Bayesian approach is a big improvement on the subjective weightings they used in the first cost-effectiveness analysis. As with publication bias, it’s reasonable to hold different views on how to construct the prior, but personally, I do believe that any psychotherapy intervention in LMICs, so long as cost per patient is <$100, is a ~certain bet to beat cash transfers. There are no specific models of psychotherapy that perform better than the others, so I don’t find it surprising that training people to talk to other people about their problems is a more cost-effective way to improve wellbeing in LMICs. Cash transfers are much more expensive and the effects on subjective wellbeing are also small.

  4. The evidential trajectory here is all to common, and the outlook typically bleak. It is dubious StrongMinds is a good pick even among psychotherapy interventions (picking one at random which doesn’t have a likely-bad-news RCT imminent seems a better bet). Although pricing different interventions is hard, it is even more dubious SM is close to the frontier of “very well evidenced” vs. “has very promising results” plotted out by things like AMF, GD, etc. HLI’s choice to nonetheless recommend SM again this giving season is very surprising. I doubt it will weather hindsight well.

  HLI had to start somewhere and I think we should give credit to StrongMinds for being brave enough to open themselves up to the scrutiny they’ve faced. The three meta-analyses and the tentative analysis of Friendship Bench suggest there is ‘altruistic gold’ to be found here and HLI has only just started to dig. The field is growing quickly and I’m optimistic about the trajectories of CE-incubated charities like Vida Plena and Kaya Guides.

  In the meantime, although the gap between GiveDirectly and StrongMinds has clearly narrowed, I remain unconvinced that cash is clearly the better option (but I do remain open-minded and open to pushback).

• Barry Grimes 23 Nov 2023 12:55 UTC

  2 points

  0 ∶ 0

  in reply to: James Snowden🔸’s comment on: Open Philan­thropy’s newest fo­cus area: Global Public Health Policy

  Thanks for providing such a thoughtful response. These value judgments are extremely difficult and it looks like you did the best you could with the evidence available. I haven’t looked into the subjective wellbeing of suicide survivors but, if there’s enough data, this could provide a helpful sense-check to your original discount rate.

  Although means restriction is very successful at reducing suicide rates, I’m curious how it compares to social determinants (or psychotherapy) if the goal is DALYs/​QALYs/​WELLBYs. It seems plausible that public health interventions that focus on improving quality of life could lead to a larger overall benefit (for a larger population) than ones that focus solely on reducing suicides (depending on philosophical views of course!)

• Barry Grimes 21 Nov 2023 15:29 UTC

  15 points

  4 ∶ 0

  on: Open Philan­thropy’s newest fo­cus area: Global Public Health Policy

  I’m very pleased to see public health become a distinct part of OP’s portfolio. In particular, the continued support for suicide prevention is very welcome.
  
  I’m curious about how you model the future wellbeing of the people whose suicides are prevented. Given that your focus is on LMICs, it’s very unlikely they’ll receive mental health treatment, so what happens to them? Do they make a full recovery or do they (and their families) continue to suffer?
  
  I don’t think this was your intention, but this post implies that OP only cares about reducing the deaths and you’re not planning to do anything to alleviate the suffering.
  
  Within the field of global mental health, there is growing interest in how to influence social determinants of mental health. Lund (2023) makes some tentative suggestions for public health interventions which may be of interest to you.

• Barry Grimes 23 Jun 2023 19:39 UTC

  7 points

  1 ∶ 3

  on: Cor­rectly Cal­ibrated Trust

  This is a very half-baked idea, but most trust-based services (e.g. Uber, Airbnb, Trustpilot) seem to have settled on five-star ratings and/​or reviews as a solution. Perhaps you could experiment with adding similar functionality to EA Forum profiles for orgs and/​or individuals, although I’m sceptical the benefits would outweigh the potential downsides.

• Barry Grimes 23 Jun 2023 19:01 UTC

  13 points

  3 ∶ 0

  in reply to: Justin Sandefur’s comment on: How economists got Africa’s AIDS epi­demic wrong

  I noticed that much of the political tractability discussion has focussed on counterfactuals involving other diseases (e.g. malaria) but I’m more confused why the government prioritised treatment over prevention.
  
  Oster’s article argued that prevention would be a better bet than treatment and that was written in 2005 when Congress had approved the budget and the prices of the drugs had come down. You also highlight the importance of, “the evidence from those who had worked in the field that antiretroviral drugs and preventive measures could be deployed effectively and at reasonable cost, even in very poor settings”. (emphasis added)
  
  So both options had evidence of feasibility and efficacy, the money was already there, and it seems like, at that time, they didn’t know which option would scale better or get cheaper quicker.
  
  I’m struggling to see what Oster got wrong. Was the decision to prioritise treatment over prevention mostly driven by the emotional appeal of the ‘Lazarus effect’?

£50k for bold/​novel/​weird ideas to ac­cel­er­ate men­tal health research

• Barry Grimes 24 Jan 2023 10:23 UTC

  3 points

  1 ∶ 2

  in reply to: alexhill’s comment on: The Ca­pa­bil­ity Approach

  That’s good to know, thanks for clarifying. A democratic process is definitely better than a top-down approach, but everyone who participates in that process will be subject to affective forecasting biases too. That’s why I favour using subjective wellbeing data, but I’m keen to hear about alternative options too.

• Barry Grimes 19 Jan 2023 11:20 UTC

  6 points

  1 ∶ 0

  in reply to: Henry Howard🔸’s comment on: Eval­u­at­ing StrongMinds: how strong is the ev­i­dence?

  Hi Henry. Thanks for your feedback! I’ll let Joel respond to the substantive comments but just wanted to note that I’ve changed the “Appendix D” references to “Appendix C”. Thanks very much for letting us know about that.
  
  I’m not sure why Appendix B has hyperlinks for some studies but not for others. I’ll check with Joel about that and add links to all the papers as soon as I can. In future, I plan to convert some of our data tables into embedded AirTables so that readers can reorder by different columns if they wish.