I agree there should be more reflection (moral or factual) into the assumption that we should prioritize preventing human extinction. :)
That being said, we should emphasize that some of the risk factors for extinction also seem to be risk factors for more suffering and s-risks—which suggests that negative utilitarians as well as s-risk reducers wouldn’t support shifting focus away from those dealing with those risk factors—unless there are better opportunities for impact. Examples of these risk factors include more conflict, polarization and the unsafe development of AI, especially without concern for cooperative aspects to prevent potential conflict between different AI or their operators.
Of course, this might not apply to all risk factors of extinction. Still, s-risk reducers and suffering reducers might think that it’s bad to (intentionally or otherwise) act in a way that results in people trying to bring it about (see https://www.utilitarianism.com/nu/nufaq.html#3.2 ) which might raise the question of precisely how much emphasis to put on this as a community.
More considerations include whether other civilizations exist (e.g. aliens), and if so, how many. This also makes it unclear what antinatalism suggests. If the focus is on fewer births then we need to find out whether human civilization would increase or decrease the total number of births in the future compared to alternative scenarios where, e.g., aliens own the resources humans would have owned.
Also remember that an existential risk (x-risk) is a “risk of an existential catastrophe, i.e. one that threatens the destruction of humanity’s longterm potential”. This means existential risks aren’t the same as extinction risks. S-risks that destroy humanity’s longterm potential are also x-risks.
That’s an excellent point. If analgesics also reduce reflex responses towards noxious stimuli, then in some cases analgesics could be diminishing nociceptive responses while not inhibiting conscious (reportable) pain.
I don’t know much about how analgesics affect nociceptive reflexive responses in humans. According to the abstract of this study on non-human primates (haven’t looked into the study in detail), “depending on the dose, nociceptive reflexes [are] facilitated or inhibited” by morphine. So this possibility might prevent us from updating too much to “analgesics are preventing pain when they inhibit nociception” to the extent that the analgesics are inhibiting reflexive nociceptive responses.
One way this might not be an issue is if someone thinks consciousness is “smeared spatially and temporally” or if they think nested minds are possible. For them, through analogies in function, they might think the reflexive responses themselves could be in pain. But then again, there are probably fewer people who think like this than people who think invertebrates feel pain.