RSS

Biosurveillance

TagLast edit: 14 Jul 2022 21:05 UTC by Leo

Biosurveillance, in the context of biosecurity, is the detection and monitoring of biological agents to prevent biological threats. This is most commonly associated and achieved via metagenomic sequencing, the readout of the totality of nucleic acids (DNA and RNA) present in an environmental sample.

Examples

A prominent biosurveillance implementation is BioWatch, a US federal program designed to detect the release of known pathogens in 21 American cities. It mainly focuses on detecting airborne releases and subsequent PCR-based testing against a list of candidate pathogens. BioWatch has, however, been criticised for failing to respond to known threats while sounding false-positive alarms.

An unbiased, metagenomic sequencing-based proposal is the Nucleic Acid Observatory. It aims to detect any changes in the presence and composition of nucleic acids in major waterways and sewage, thus recognising emerging pathogens as early as possible.

Further reading

Fox, Ben (2021) Audit finds major gaps in US bio weapons detection system, AP News, March 4.

Nieuwenhuijse, David F. et al. (2020) Setting a baseline for global urban virome surveillance in sewage, Scientific Reports, vol. 10, 13748.

Shea, Dana A. & Sarah A. Lister (2003) The Biowatch Program: Detection of bioterrorism, Report No. RL32152, Congressional Research Service.

The Nucleic Acid Observatory Consortium (2021) A global nucleic acid observatory for biodefense and planetary health, arXiv:2108.02678.

Related entries

biosecurity | COVID-19 pandemic | global catastrophic biological risk | metagenomics | Nucleic Acid Observatory

An­nounc­ing the Nu­cleic Acid Ob­ser­va­tory pro­ject for early de­tec­tion of catas­trophic biothreats

Will Bradshaw29 Apr 2022 19:30 UTC
212 points
3 comments2 min readEA link

Three Rea­sons Early De­tec­tion In­ter­ven­tions Are Not Ob­vi­ously Cost-Effective

Conrad K.21 Apr 2024 21:05 UTC
64 points
4 comments16 min readEA link

Po­lio Lab Leak Caught with Wastew­a­ter Sampling

Cullen7 Apr 2023 1:06 UTC
107 points
0 comments1 min readEA link
(www.eurosurveillance.org)

Pro­ject Ideas in Biose­cu­rity for EAs

Davidmanheim16 Feb 2021 21:01 UTC
106 points
19 comments6 min readEA link

Biose­cu­rity needs en­g­ineers and ma­te­ri­als scientists

Will Bradshaw16 Dec 2021 11:37 UTC
160 points
11 comments3 min readEA link

Pre­dict­ing Virus Rel­a­tive Abun­dance in Wastewater

Jeff Kaufman10 Aug 2023 15:46 UTC
46 points
5 comments1 min readEA link
(naobservatory.org)

Con­crete pro­ject lists

Richard_Batty25 Mar 2017 18:12 UTC
46 points
49 comments2 min readEA link

Se­quenc­ing Swabs

Jeff Kaufman1 Feb 2024 1:54 UTC
24 points
8 comments1 min readEA link

De­tect­ing Ge­net­i­cally Eng­ineered Viruses With Me­tage­nomic Sequencing

Jeff Kaufman27 Jun 2024 14:01 UTC
202 points
7 comments8 min readEA link
(naobservatory.org)

Ge­netic Se­quenc­ing of Wastew­a­ter: Prevalence to Rel­a­tive Abundance

Jeff Kaufman25 Apr 2023 19:35 UTC
56 points
0 comments1 min readEA link

What are our ge­netic en­g­ineer­ing de­tec­tion ca­pa­bil­ities?

jvb16 Feb 2023 1:34 UTC
20 points
1 comment3 min readEA link

Case Rates to Se­quenc­ing Reads

Jeff Kaufman21 Sep 2022 2:00 UTC
32 points
3 comments4 min readEA link
(www.jefftk.com)

The AI Revolu­tion in Biology

Roman Leventov26 May 2024 9:30 UTC
8 points
0 comments1 min readEA link
(www.cognitiverevolution.ai)

[Question] Any in­ter­est in bac­te­riophages?

Charlie Dougherty4 May 2022 10:44 UTC
8 points
3 comments1 min readEA link

Tech­nolog­i­cal Bot­tle­necks for PCR, LAMP, and Me­tage­nomics Sequencing

Ziyue Zeng9 Jan 2023 6:05 UTC
38 points
0 comments17 min readEA link

Overview of the Pathogen Bio­surveillance Land­scape

Brianna Gopaul9 Jan 2023 6:05 UTC
54 points
4 comments20 min readEA link

(Paper Sum­mary) Manag­ing the Tran­si­tion to Wide­spread Me­tage­nomic Mon­i­tor­ing: Policy Con­sid­er­a­tions for Fu­ture Bio­surveillance

chelsea_liang19 Jan 2023 11:12 UTC
49 points
0 comments2 min readEA link
(www.liebertpub.com)

Biose­cu­rity Re­source Hub from Aron

Aron Lajko21 Jul 2023 18:07 UTC
39 points
4 comments1 min readEA link

[Opz­ionale] La biosicurezza ha bi­sogno di tec­nici e scien­ziati dei materiali

EA Italy12 Jan 2023 3:09 UTC
1 point
0 comments4 min readEA link

Ob­sta­cles to the U.S. for Sup­port­ing Ver­ifi­ca­tions in the BWC, and Po­ten­tial Solu­tions.

Garrett Ehinger14 Apr 2023 2:48 UTC
27 points
2 comments16 min readEA link

Com­par­ing sam­pling strate­gies for early de­tec­tion of stealth biothreats

slg26 Feb 2024 23:14 UTC
19 points
3 comments26 min readEA link
(naobservatory.org)

Coron­avirus Re­search Ideas for EAs

Peter Wildeford27 Mar 2020 21:01 UTC
118 points
20 comments23 min readEA link
No comments.